3D printing of hydrogel composite systems: Recent advances in technology for tissue engineering
Journal Title: International Journal of Bioprinting - Year 2018, Vol 4, Issue 1
Abstract
Three-dimensional (3D) printing of hydrogels is now an attractive area of research due to its capability to fabricate intricate, complex and highly customizable scaffold structures that can support cell adhesion and promote cell infiltration for tissue engineering. However, pure hydrogels alone lack the necessary mechanical stability and are too easily degraded to be used as printing ink. To overcome this problem, significant progress has been made in the 3D printing of hydrogel composites with improved mechanical performance and biofunctionality. Herein, we provide a brief overview of existing hydrogel composite 3D printing techniques including laser based-3D printing, nozzle based-3D printing, and inkjet printer based-3D printing systems. Based on the type of additives, we will discuss four main hydrogel composite systems in this review: polymer- or hydrogel-hydrogel composites, particle-reinforced hydrogel composites, fiber-reinforced hydrogel composites, and anisotropic filler-reinforced hydrogel composites. Additionally, several emerging potential applications of hydrogel composites in the field of tissue engineering and their accompanying challenges are discussed in parallel.
Authors and Affiliations
Tae-Sik Jang, Hyun-Do Jung, Houwen Matthew Pan, Win Tun Han, Shengyang Chen, Juha Song
Keywords
Related Articles
- EP ID EP678675
- DOI -
- Views 156
- Downloads 0
Structural, mechanical and in vitro studies on pulsed laser deposition of hydroxyapatite on additive manufactured polyamide substrate
Additive manufacturing (AM) is an emerging field that merges engineering and life sciences to produce components that can effectively act as a replacement in the human body. This AM encompasses biofabrication using cells...
Mechanism for corrosion protection of β-TCP reinforced ZK60 via laser rapid solidification
It remains the primary issue to enhance the corrosion resistance of Mg alloys for their clinical applications. In this study, β-tricalcium phosphate (β-TCP) was composited with Mg-6Zn-1Zr (ZK60) using laser rapid solidif...
3D printing of hydrogel composite systems: Recent advances in technology for tissue engineering
Three-dimensional (3D) printing of hydrogels is now an attractive area of research due to its capability to fabricate intricate, complex and highly customizable scaffold structures that can support cell adhesion and prom...
Graphene Oxide Induces Ester Bonds Hydrolysis of Poly-l-lactic Acid Scaffold to Accelerate Degradation
Poly-l-lactic acid (PLLA) possesses good biocompatibility and bioabsorbability as scaffold material, while slow degradation rate limits its application in bone tissue engineering. In this study, graphene oxide (GO) was i...
A novel 3D printing method for cell alignment and differentiation
The application of bioprinting allows precision deposition of biological materials for bioengineering applications. Here we propose a 2 stage methodology for bioprinting using a back pressure-driven, automated robotic di...