3D QSAR STUDIES OF BENZIMIDAZOLE DERIVATIVES AS FtsZ INHIBITORS
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2018, Vol 7, Issue 11
Abstract
Tuberculosis is one of the most infectious disease in the world. Filamentous Temperature Sensitive Mutant Z gene (FtsZ) being a strong target implies an efficacious therapy for tuberculosis treatment. Amongst the entire moieties which are currently under research, Benzimidazole plays a vital role in the field of drug discovery and development. In the current paper, Three dimensional quantitative structure activity relationship (3D QSAR) studies were performed on 2,5,6- tri-substituted benzimidazole derivatives. The studies were carried out to know the structural requirements of Filamentous Temperature Sensitive Mutant Z gene (FtsZ) agonists. Using various techniques the model possessed high arithmetical reliability and good predictive power. Consequently, the results obtained may provide important information in further optimization of benzimidazole derivatives as Filamentous Temperature Sensitive Mutant Z gene (FtsZ) agonists.
Authors and Affiliations
Kavan M. Jani
Keywords
Related Articles
- EP ID EP628112
- DOI -
- Views 155
- Downloads 0
A LOCALLY SYNTHESIZED PROBIOTIC FOR MAINTAINING IMMUNE SYSTEM FUNCTIONS IN IMMUNOCOMPROMISED NZW RABBITS
This study aimed to develop a novel probiotic, using microorganisms isolated and identified from rabbit‟s colon, for developing a nutritional supplement to maintain and treat the weaken immune system responses in immunoc...
EFFECT OF POLY (ADP-RIBOSE) POLYMERASE INHIBITION ON MORPHO-FUNCTIONAL STATE OF IMMUNOCYTES UNDER THE CONDITION OF EXPERIMENTAL ENDOTOXEMIA IN MICE
Recent in vivo and in vitro evidence suggest that inhibitors of poly (ADP-ribose) polymerase (PARP)-1 could be promised in the treatment of inflammatory disorders and conditions associated with an inflammatory component....
CURRENT TRENDS IN DRUG PRODUCT REGISTRATION DOCUMENTATION AND HIGHLIGHTING OF LEGISLATED REGULATORY GUIDELINES
Regulatory affairs profession is the bridge between pharmaceutical industries and regulatory bodies across world. It is mainly involved in registration of drug products in respective countries prior to marketing. In curr...
ANTICANCER ACTIVITY OF MESOIONIC SYDNONES: AN UPDATES ON REVIEW
Sydnones are unique nitrogenous compounds and chemically 1, 2, 3-oxadiazolium-5-olates. A large number of sydnones showed extensive range of medicinal values like antibacterial, antifungal, anti-inflammatory, antitumor,...
DEVELOPMENT AND VALIDATION OF A SIMPLE RP-HPLC METHOD FOR THE ESTIMATION OF ATORVASTATIN IN SELF EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS)
A simple, selective and rapid reversed phase High Performance Liquid Chromatographic (RP-HPLC) method for the analysis of atorvastatin in self emulsifying drug delivery system (SEDDS) has been developed and validated. Th...