DEVELOPMENT AND VALIDATION OF A SIMPLE RP-HPLC METHOD FOR THE ESTIMATION OF ATORVASTATIN IN SELF EMULSIFYING DRUG DELIVERY SYSTEM (SEDDS)
Journal Title: WORLD JOURNAL PHARMACY AND PHARMACEUTICAL SCIENCE - Year 2019, Vol 8, Issue 4
Abstract
A simple, selective and rapid reversed phase High Performance Liquid Chromatographic (RP-HPLC) method for the analysis of atorvastatin in self emulsifying drug delivery system (SEDDS) has been developed and validated. The chromatographic system consisted of a LC-20 AT pump, SPD-20 A UV/visible detector. The separation was achieved from C18 column at 300C with a mobile phase consisting of 0.025 M phosphoric acid solution: acetonitrile (60:40 v/v, pH 3.0 adjusted with 80% phosphoric acid) at a flow rate of 1.2 ml/min and the retention time was 2.737± 0.019 min. The method was found selective and able to resolve drug peaks from formulation excipients. The calibration curve was linear over the concentration range of 2-20 μg/ml (r2 = 0.999). The proposed method was accurate with 100.14 ± 0.57% recovery and precise (%RSD of Intraday variation were 0.55% and 0.58% for Inter day variation). The method has been used to determine potency of prepared SEDDS. Potency in all the cases was found within 99.02%- 100.02%. Therefore, this method can be used as a more convenient and efficient option for the analysis of atorvastatin in self emulsifying drug delivery system (SEDDS).
Authors and Affiliations
Prof. Dr. SM Ashraful Islam
Keywords
Related Articles
- EP ID EP667344
- DOI -
- Views 129
- Downloads 0
TRANSFORMING GROWTH FACTOR-ΒETA 1 AN EARLY PREDICTOR OF DIABETIC NEPHROPATHY
Objectives: The common complication of diabetes is nephropathy which is a leading cause of renal failure in one third of patients undergoing dialysis. Transforming growth factor-beta 1 (TGF-β1) plays a crucial role in th...
SHATAVARI (ASPARAGUS RACEMOSUS) A AYURVEDIC DRUG REVIEW
Ayurveda is an ancient and the oldest medical system in the world. Dating back almost 5000 years, it is also considered to be an ancient science of healing that enhances longevity. Herbal medicines are considered to be s...
COMPARATIVE STUDY OF THE ANTIMICROBIAL, MINIMUM INHIBITORY CONCENTRATIONS (MIC), CYTOTOXIC AND ANTIOXIDANT ACTIVITY OF METHANOLIC EXTRACT OF DIFFERENT PARTS OF PHYLLANTHUS ACIDUS (L.) SKEELS (FAMILY: EUPHORBIACEAE)
The main aim of this study was to find out and compare the antimicrobial, cytotoxic, antioxidant activity along with the minimum inhibitory concentrations (MIC) of methanolic extract of different parts of Phyllanthus aci...
ANTIBIOTIC DISPENSING WITHOUT PRESCRIPTION IN COMMUNITY PHARMACIES, DHAMAR PROVINCE, YEMEN
Background: The dispensing of antibiotics without medical prescription has been observed in many countries, particularly, in developing countries, including Yemen, where the legislations and regulations are weak. Objecti...
THE ECONOMIC OUTCOMES OF THE MEDICATION SAFETY OFFICER IN THE CARDIOLOGY SPECIALTY
Introduction: no studies highlighted the economic outcomes of the medication safety officer position in cardiology specialty in the Middle East hospitals. Objective: to determine the economic outcomes of the medication s...