A Comparative Study Of Concomitant Chemo-Irradiation With Mitimycin –C & FFU Versus Conventional Radiotherapy Alone In Advanced Cases (IIB – IVA) Of Carcinoma Of Uterine Cervix
Journal Title: National Journal of Medical and Dental Research - Year 2018, Vol 6, Issue 4
Abstract
Background-Over the years, improvements in radiotherapy techniques, the result of treatment in advanced cases of Ca Cx (carcinoma uterine cervix) have not changed and remains between 30 – 40 % in the best of centers. In order to achieve better response rate and survival, various techniques have been used including radio-sensitizers, hyperbaric oxygen, altered fractionation schedules, concomitant chemoirradiation and combined surgery and radiotherapy. Patients and methods-A clinical study using conventional radiation 2 Gy / fractions / 5 fractions per week in one arm and concomitant chemoirradiation with Mitomycin C (MMC) & 5 Fluorouracil (FFU) in second arm was carried out in advanced cases of carcinoma of uterine cervix (IIB – IVA). The observations made were used to compare the response to treatment and complications/toxicities of the two types of treatments. At cancer hospital Jabalpur, we used conventional radiation in 100 cases of histological proven and clinically staged advanced squamous cell carcinoma of uterine cervix (Ca Cx). 50 cases received concomitant chemotherapy with MMC + FFU along with conventional radiation and 50 cases received radiation alone. Results –In this study of 100 patients, it was observed that concurrent chemoirradiation was associated with acceptable toxicities. Complete response to treatment was better in chemoirradiation arm 63.3% as compared to 45.4% in conventional radiotherapy alone.
Authors and Affiliations
Ashutosh Agnihotri, Aditya Narayan
Keywords
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