A Comparative Study of Dexmedetomidine HCL and Esmolol HCL for Attenuating Pressor Response to Laryngoscopy and Oral Endotracheal Intubation
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2018, Vol 5, Issue 9
Abstract
Introduction: Laryngoscopy and intubation increases sympathetic activity resulting in tachycardia and hypertension which may cause myocardial ischemia, cardiac arrhythmias and cerebrovascular hemorrhage. We compared the efficacy of intravenous esmolol and dexmedetomidine to attenuate the pressor response to laryngoscopy and intubation. Design: Randomised controlled trial. Method: Seventy-five patients of ASA I and ASA II undergoing general anesthesia with oral intubation for elective surgery were allocated into three groups.Group C: Control group. Group E: intravenous esmolol 2mg/kg three minutes before laryngoscopy. Group D: Intravenous dexmedetomidine 1g/kg in 100ml infusion over ten minutes before laryngoscopy. Heart rate, systolic, diastolic and mean arterial pressures were recorded before drug administration, after drug administration, after induction of standard anesthesia, immediately after intubation, every 2 minutes till 10 minutes. Incidence of bradycardia and hypotension were noted. Statistical Analysis used: IBM SPSS version. Results: Mean HR immediately after intubation for group C was (104.57±8.2) whereas it was (83±4.53, 92.6±4.70) for group D and group E with p value of (0.003,0.002) when compared to control group. While comparing group D and E, p value was 0.0001. MAP immediately after intubation for group C was (109±5.9) whereas it was (98±3.4, 100.2±5.2) for group D and E with p value (0.0001, 0.002) when compared to control group. While comparing group D and E, p value was 0.006. Conclusion: Dexmedetomidine and esmolol both attenuated the pressor response to laryngoscopy and intubation but it was better controlled with dexmedetomidine.
Authors and Affiliations
Patel Leena
Keywords
Related Articles
- EP ID EP539134
- DOI 10.21088/ijaa.2349.8471.5918.13
- Views 80
- Downloads 0
Comparison of Two Different doses of Clonidine Hydrochloride as an Adjuvant to Epidural Bupivacaine for Postoperative Analgesia
Context: The study was planned to assess the comparative efficacy, duration of analgesia block characteristics and hemodynamic or any adverse events on combining clonidine in two different doses with epidural Bupivacaine...
A Critical Evaluation of an Effect of Nalbuphine as an Adjuvant to Bupivacaine for Ultrasound Guided Interscalene Brachial Plexus Block
Context: The use of Brachial plexus block under Ultrasound guidance for Anesthesia has increased recently. Various adjuvants are added to enhance the analgesic effect of local anesthetic agents namely opioids, alpha 2 a...
Intrathecal Nalbuphine versus Intrathecal Dexmedetomidine for Postoperative Analgesia of Lower Abdominal and Lower Limb Surgeries
ntroduction: Opioids are used as adjuncts with the local anaesthetic for longer duration of action and better postoperative analgesia [4]. Nalbuphine, is a mixed agonist-antagoniste and its analgesic potency is equal to...
Effect of Clonidine and Dexmedetomidine on Haemodynamic and Recovery Responses During Tracheal Extubation: A Randomised DoubleBlind Comparative Study
Background and Aims: Emergence from anaesthesia and tracheal extubation are associated with transient surge in catecholamines due to sympathetic stimulation causing hypertension, tachycardia, myocardial ischaemia etc. Va...
Real-time Ultrasound-Guided Catheterization of the Internal Jugular Vein: A Prospective Comparison with the Landmark Technique
Introduction: Conventionally central venous catheter is done utilising landmark technique. With increased availability of portable USG units, USG-guided intervention is fast gaining acceptance as a valuable tool in the c...