A Comparative Study of Dexmedetomidine HCL and Esmolol HCL for Attenuating Pressor Response to Laryngoscopy and Oral Endotracheal Intubation
Journal Title: Indian Journal of Anesthesia and Analgesia - Year 2018, Vol 5, Issue 9
Abstract
Introduction: Laryngoscopy and intubation increases sympathetic activity resulting in tachycardia and hypertension which may cause myocardial ischemia, cardiac arrhythmias and cerebrovascular hemorrhage. We compared the efficacy of intravenous esmolol and dexmedetomidine to attenuate the pressor response to laryngoscopy and intubation. Design: Randomised controlled trial. Method: Seventy-five patients of ASA I and ASA II undergoing general anesthesia with oral intubation for elective surgery were allocated into three groups.Group C: Control group. Group E: intravenous esmolol 2mg/kg three minutes before laryngoscopy. Group D: Intravenous dexmedetomidine 1g/kg in 100ml infusion over ten minutes before laryngoscopy. Heart rate, systolic, diastolic and mean arterial pressures were recorded before drug administration, after drug administration, after induction of standard anesthesia, immediately after intubation, every 2 minutes till 10 minutes. Incidence of bradycardia and hypotension were noted. Statistical Analysis used: IBM SPSS version. Results: Mean HR immediately after intubation for group C was (104.57±8.2) whereas it was (83±4.53, 92.6±4.70) for group D and group E with p value of (0.003,0.002) when compared to control group. While comparing group D and E, p value was 0.0001. MAP immediately after intubation for group C was (109±5.9) whereas it was (98±3.4, 100.2±5.2) for group D and E with p value (0.0001, 0.002) when compared to control group. While comparing group D and E, p value was 0.006. Conclusion: Dexmedetomidine and esmolol both attenuated the pressor response to laryngoscopy and intubation but it was better controlled with dexmedetomidine.
Authors and Affiliations
Patel Leena
Keywords
Related Articles
- EP ID EP539134
- DOI 10.21088/ijaa.2349.8471.5918.13
- Views 91
- Downloads 0
Efficacy of Right Superficial Cervical Plexus Block and Intravenous Dexmedetomidine for Relief of Shoulder Pain in Laparoscopic Surgery Under Spinal Anaesthesia: A Feasibility Study
Background and Aim: Laparoscopic procedures are conventionally done under general anaesthesia for avoiding patient discomforts and shoulder pain due to pneumoperitoneum that occur during laparoscopy under spinal anaesthe...
A Study to Compare the Effects of Low Dose Intrathecal Fentanyl and Low Dose Intrathecal Tramadol Combined with 0.5% Bupivacaine (Heavy) in Patients Undergoing Orthopaedic Surgeries
Introduction: Relief of pain during operation and postoperative period is one of the main stay of balanced anaesthesia. Bupivacaine Hydrochloride is known for long procedures due to prolonged action. The addition of opio...
Preventive Analgesic Efficacy of Intravenous Tramadol Versus Intravenous Nalbuphine for Elective Inguinal Hernia Repair Surgeries :Randomised Controlled Trial
Background Information: One of the challenges in postoperative care in a developing country is the non-availability of narcotics. Morphine and fentanyl have excellent analgesic action but they are difficult procure as th...
Mechanical Complications during Insertion of Central Venous Catheter in Subclavian Vein and Internal Jugular Vein: A Comparative Study
Background: Central venous catheters (CVC) are an essential component of modern critical care. They allow delivery of medications, intravenous fluids, parenteral nutrition, hemodialysis and monitoring of hemodynamic vari...
A Study on the Efficacy of Ketamine Given Intrathecallyas A Spinal Anesthetic Agent
Ketamine a phencyclidine derivative with potent analgesic properties possesses few advantages over the other local anesthetics as it tends to stimulate the cardiovascular system and maintains the respiratory response to...