A comparative study of renal function tests in hypertensive patients
Journal Title: INTERNATIONAL JOURNAL OF RECENT TRENDS IN SCIENCE AND TECHNOLOGY - Year 2016, Vol 20, Issue 3
Abstract
Introduction: -Hypertension is an important public health challenge in both economically developing and developed countries. Hypertension is defined as sustained increase at or above 140 mmHg of Systolic blood pressure (SBP) and 90 mmHg of diastolic blood pressure (DBP). Hypertensive nephropathy or renal disease occurs as a result of high blood pressure in hypertensive patient. This disease is characterized by damage to the vasculature of the kidneys as blood pressure increases. Proteinuria is closely associated with hypertension, presumably reflecting the severity of hypertension induced renal damage. Objectives: The objectives of the present study were to compare the parameters of renal function in hypertensive (HTN) patients with and without renal failure. Material and Methods: Total 118 Hypertensive patients, of age group 18-60 years were included in this study. Detailed history was taken and renal function tests were done in all the patients. Results: In the present study, Serum urea (p<0.001) and creatinine (p<0.001) levels were found to be significantly higher in cases as compared to those normal subjects. In hypertensive patients with renal failure, significant correlation was found between SBP and creatinine clearance as compared to normal subjects (correlation coefficient -0.27) and significant correlation was also found between SBP and level of serum urea (correlation coefficient -0.4). Conclusion: Proteinuria with high BP is an indicator of declining kidney function. We can also use other parameters as random urine protein-creatinine ratio for the prediction of significant proteinuria in HTN patients. The role of all the parameters needs to be further studied by increasing the number of patients and prolonging the duration of the study.
Authors and Affiliations
Basant Joshi, Sangeeta Singh, Suman Pandey
Keywords
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