A Comparative Study On Antidiabetic Effects Of Ethanol Extract Of Origanum majorana And Indigofera Linnaei Ali On Streptozotocin Induced Diabetic Rats
Journal Title: American Journal of PharmTech Research - Year 2018, Vol 8, Issue 0
Abstract
The evaluation of plant products on the basis of medicinal and therapeutic properties forms a platform for the discovery of newer drug molecules from different plant sources. To compare anti-diabetic effect between two ethanolic extracts of selected plants locally available in Bobbili region, Vizianagaram district, Andhra Pradesh, India on Streptozotocin induced diabetic rats. To compare anti-diabetic study, experimental rats were divided into five groups viz. Group I (Control), Group II (Diabetic, Streptozotocin, 50mg/kg bwt, i.p.), Group III (Diabetic with Glibenclamide(4mg/kg)), Group IV (Diabetic with Origanum majorana) and Group V (Diabetic with Indigofera linnaei Ali). Both plants extracts were supplemented with same dose i.e. 100mg/kg b.wt, orally. The blood glucose levels, lipid profile, body weight were evaluated in all above experimental groups before and after diabetes induction in 21 days pharmacological evaluation. Significantly decreased blood glucose level and simultaneously improved lipid profile and body weight in Group IV rats after oral administration of ethanol extract whereas in Group V rats are showing less effect compare to Group IV rats. Both the plant extracts effect compare with Group II and Group III rats statistically. Origanum majorana shows better antidiabetic activity because the leaf contain huge amount of antidiabetic phytoconstituents like rutin and quercetin flavonoids. In Indigofera linnaei Ali whole plant ethanol extract also shows antidiabetic activity because it contains kaempferol like important antidiabetic active constituents. Origanum majorana and Indigofera linnaei Ali plants may be used as a dietary supplement in diabetic patients. Further study is required to evaluate the antidiabetic activity.
Authors and Affiliations
Bimala Tripathy
Keywords
Related Articles
- EP ID EP619031
- DOI 10.21276/ajptr.2018.08.01.11
- Views 197
- Downloads 0
Development of Naringenin Nanocrystals for Enhanced Solubility and Bioavailability
Naringenin is a flavonoid which has been used for its wide pharmacological action from ancient years including as antidiabetic agent. Naringenin is a lipophilic drug (BCS-II) and have low water solubility (1 in 1000), bi...
A Comparative Study On Antidiabetic Effects Of Ethanol Extract Of Origanum majorana And Indigofera Linnaei Ali On Streptozotocin Induced Diabetic Rats
The evaluation of plant products on the basis of medicinal and therapeutic properties forms a platform for the discovery of newer drug molecules from different plant sources. To compare anti-diabetic effect between two e...
Analytical Method Development and Validation for Enrofloxacin in Bulk and Formulation by RP-HPLC Method
Enrofloxacin (EFX) is a third generation Fluoroquinolone with a broad spectrum antibacterial activity. Enrofloxacin hydrochloride is 1-cyclopropyl-7-(4-ethylpiperazin-1-yl)-6-fluoro-4-oxo-1, 4-dihydroquinoline-3-carboxyl...
Stability Indicating UPLC Method Development and Validation for Simultaneous Determination of Ertugliflozin and Sitagliptin
A selective, robust, economic and short method was developed for the simultaneous estimation of the Ertugliflozin (EGZ) and Sitagliptin (SGP) in Tablet dosage form. Chromatogram was run through X-bridge c18 50 x 2.1 mm,...
Molecular Interaction and Excess Thermodynamic Parameters In Binary Liquid Mixture Through Ultrasonic Measurements at 313.15 K
Experimentally determined values of density ( ρ), viscosity (η) and ultrasonic velocity (u) have been measured for the binary liquid mixture toluene and 1,2 dichloroethane at 313.15K. From these data the thermodynamic...