A COMPARATIVE STUDY ON THE ASSESSMENT OF RISKY LIPID PROFILES AMONG TWO RETROVIRAL THERAPEUTIC STRATEGIES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 6
Abstract
Presently there are a number of different anti-retroviral therapeutic strategies and regimens available, which are classified, based on the retroviral life-cycle stage the drug impacts on. Two among them for the present interest are Non-Nucleoside reverse transcriptase inhibitors (NNRTI) and protease inhibitors. The chosen drugs of the above said category are nevirapine and lopinavir/ritonavir. Present study is designed to assess the risk of hosting the ailment related to abnormal lipid profiles associated with the use of protease inhibitor regimen lopinavir/ritonavir and non-nucleoside reverse-transcriptase inhibitor nevirapine. Our results, particularly in terms of an increased risk of abnormal lipid profiles in patients receiving lopinavir/ritonavir and a reduced risk in patients receiving NNRTIs, particularly nevirapine, therefore, may give the NNRTI regimens an advantage over current PI-containing regimens. The outcomes of the present work conclude the point that treatment methods of HIV infected patients should be rationalized to reduce side effects particularly in the aspect of abnormal lipid profiles during treatment to reduce the risk of dyslipidemia and associated disorders. The work particularly says that nevirapine is safe to use in comparison with lopinavir/ritonavir combination.
Authors and Affiliations
Bhavani V. , Kiranmayi B.
Keywords
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- EP ID EP105943
- DOI 10.7897/2230-8407.06673
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