A Histo-Morphological Study on the Effects of Aging in Human Adrenal Glands
Journal Title: Indian Journal of Pathology: Research and Practice - Year 2019, Vol 8, Issue 4
Abstract
Background: Aging in humans is characterised by a selective decline in circulating levels of adrenal androgens, whose production in Zona Reticularis (ZR) of adrenal is enhanced by Cytochrome-B5 (CytB5). Objectives: The present work aims to determine the histomorphological effects of aging and CytB5 distribution in the adult human adrenal cortex during the aging process. Methods: This is an analytical study in which human adult adrenal glands were obtained at autopsy from 39 men and 33 women who suffered a sudden death. The right & the left adrenal glands were received separately and Gross findings, microscopic features and Immunohistochemistry with CytB5 were studied in detail. Results: The mean of weight, length & breadth of both Right & Left adrenal glands were found to decrease with increasing age, which is statistically significant, but without significant difference in the thickness of adrenal glands. The thickness of ZR and expression of CytB5 also showed statistically significant reduction with increasing age. The area which was histologically identified as ZR on H & E staining, corresponded well to the area of CytB5 positivity on IHC.
Authors and Affiliations
A Sharmila
Keywords
Related Articles
- EP ID EP670140
- DOI 10.21088/ijprp.2278.14810.8519.1
- Views 91
- Downloads 0
Reproducibility of Modified Gleason Scoring System and Grade Group in Prostate Carcinoma on Microphotographs
Background: Pathologists can quickly transmit the microscopic images photographed in a certain location to remote centers for analyzing the images. Gleason scoring system forms an important prognostic parameter for thera...
Pattern of Leukemia in the Multi-Ethnic and Racial Population: A Hospital Based Study
Background: The purpose of this study was to analyze the trends in the incidence rates of major types of leukemia viz. acute myelogenous leukemia (AML), acute lymphocytic leukemia (ALL), chronic myelogenous leukemia (CML...
Granulomatous Mastitis: A Masquerading Entity
Introduction: Granulomatous mastitis (GM) is a rare chronic inflammatory lesion of breast of unknown etiology. This entity clinically and radiologically may simulate carcinoma and presents as palpable breast lump with hi...
Adrenal Myelolipoma: Report of 2 Cases of a Rare Tumour
Introduction: Myelolipoma was described initially by Gierke in 1905 and the term was coined by Obenling in 1929. These are rare benign tumours of the adrenal gland with a cited estimated autopsy prevalence of 0.1-0.2%....
Clinico-Hematological Study of Megaloblastic Anemia and Associated Megakaryocytic Alterations
Context: Megaloblastic anemias are hematological disorders in which nuclear maturation lags behind the cytoplasmic maturation. Thrombocytopenia in megaloblastic anemia is because of ineffective thrombopoiesis in some stu...