A PROSPECTIVE RANDOMISED CONTROL STUDY TO ASSESS THE EFFICACY OF INTRAOPERATIVE DEXMED INFUSION ON EMERGENCE AGITATION AND QUALITY OF RECOVERY IN NASAL SURGERY
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 8
Abstract
BACKGROUND Emergence agitation is usually common after nasal surgery. We underwent investigation to find the effects of intraoperative dexmedetomidine infusion on emergence agitation and quality of recovery after nasal surgery in adult patients. MATERIALS AND METHODS One hundred patients undergoing nasal surgery were randomized into two groups. The dexmedetomidine group (Group D, n=50) received dexmedetomidine infusion at a rate of 0.4 mcg/kg/hr from induction of anaesthesia until extubation, while the control group (Group C, n=50) received volume-matched normal saline infusion as placebo. Propofol 1.5-2 mg kg/kg and fentanyl 1 mcg/kg were used for induction of anaesthesia, and sevoflurane was used for maintenance of anaesthesia. The incidence of agitation, haemodynamic parameters, and recovery characteristics were evaluated during emergence. A 40-item quality-ofrecovery questionnaire (QoR-40) was provided to patients 24 h after surgery. RESULTS The incidence of agitation was lower in Group D than Group C (28 vs 52%, P=0.041). Mean arterial pressure and heart rate were more stable in Group D than in Group C during emergence (P<0.05). Time to extubation and respiratory rate at extubation were similar between the groups. Global QoR-40 score at 24 hrs. after surgery was higher in Group D (median [range], 183 [146 -198]) compared with Group C (178 [133-196]) (P=0.041). CONCLUSION Intraoperative infusion of dexmedetomidine provided smooth and haemodynamically stable emergence. It also improved quality of recovery after nasal surgery.
Authors and Affiliations
Manimaran R, Aravind K
Keywords
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- EP ID EP410136
- DOI 10.14260/jemds/2018/222
- Views 95
- Downloads 0
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