A Review of MicroRNA in Carcinogenesis
Journal Title: International Journal of Experimental Research and Review - Year 2016, Vol 8, Issue 7
Abstract
MicroRNAs (miRNAs) are small RNAs involved in regulation of several cellular processes which are involved in the silencing of cell’s message in various processes. They are class of 21- to 24-nucleotides (nt), non-coding, regulatory RNA molecules, was first discovered in developing nematode. After the discovery of the first miRNA in the roundworm C. elegans, these short regulatory RNAs have been found to be an abundant class of RNAs in plants, animals, and DNA viruses. About 3% of human genes encode for miRNAs, and upto 30% of human protein coding genes may be regulated by miRNAs. MicroRNAs play a key role in diverse biological processes, including development, cell proliferation, differentiation and apoptosis. Accordingly, altered miRNA expression is likely to contribute to human disease, including cancer. Recent findings indicate that carcinogenic processes are associated with alteration in the expression of several microRNAs. Furthermore finding suggested that some microRNAs have got cancer promoting role (as oncogene) and the others act as tumour suppressor genes. In this review we illustrate the specific role and relationship of microRNA in a wide variety of cancer and also the application of microRNA in cancer detection as biomarker as well as therapeutic potential.
Authors and Affiliations
Paromita Bhattacharjee; Syamasri Mukherjee
Keywords
Related Articles
- EP ID EP702145
- DOI -
- Views 109
- Downloads 0
Tourism caused jeopardize of biodiversity: a case study on Mandermoni –Dadanpatrabarh coastal tourist destination in Purba Medinipur district, West Bengal, India
The present study is conducted to correlate among tourism and biodiversity, environment , physical and socio-cultural landscape. Tourism is now a major contributor to foreign exchange, money earnings and provides employm...
Screening for Chronic Obstructive Pulmonary Disease in Patients with Coronary Artery Disease at a Tertiary Care Hospital
Chronic Obstructive Pulmonary Disease is a common, preventable and treatable disease that is characterized by persistent respiratory symptoms and airflow limitation that is due to airway and/or alveolar abnormalities usu...
Fabrication of microspheres and characterization of antimicrobial and anti-inflammatory activity isolated fraction from total alcoholic extract of Cassia Fistula (Linn.) in carrageenan-Type-IV induced inflammatory rats
The Cassia fistula Linn is known as the golden shower tree. It’s also referred to as a "disease killer" in Ayurvedic medicine. The current study investigates the effect and estimate of antimicrobial and Anti-inflammatory...
Machine Learning-Based Gesture Recognition for Communication with the Deaf and Dumb
A deep learning model specifically designed to recognize signs in sign language is the foundation of the Sign Language Recognition system. Sign Language is a visual language used by the deaf and hard of hearing community...
Influence of Phosphate on Arsenic Uptake and Activities of Different Phosphatase Enzymes in Growing Rice (Oryza sativa L.) Seedlings
The effect of arsenate on the levels of phosphate contents and activities of different phosphorolytic enzymes were studied in ten days of rice seedlings var. MTU-1010. Total arsenic contents were increased both in root a...