Recent progress in the computational prediction of aqueous solubility and absorption

The computational prediction of aqueous solubility and/or human absorption has been the goal of many researchers in recent years. Such anin silico counterpart to the biopharmaceutical classification system (BCS) would ha...

Effect of Ethanol on Opioid Drug Permeability Through Caco-2 Cell Monolayers

Ethanol significantly increased the permeability of oxycodone, oxymorphone and atenolol in a concentration-dependent (1–5%) manner. The permeability of hydromorphone and metoprolol were not altered by ethanol. Th...

Corrigendum: Population pharmacokinetics of S(-)-carvedilol in healthy volunteers after administration of the immediate-release (IR) and the new controlled-release (CR) dosage forms of the racemate

Kinetic modeling of plasmid DNA degradation in rat plasma

A major obstacle in gene delivery is the transport of intact plasmid DNA (pDNA) to target sites. We sought to investigate the kinetic processes underlying the degradation of pDNA in a rat plasma model, as this is one of...

Influence of degree of polymerization on behavior of cellulose during homogenization and extrusion/spheronization

The study objective was to investigate the influence of the degree of polymerization (DP) of cellulose materials (microcrystalline cellulose [MCC] and powder cellulose [PC]) on the behavior of these materials during homo...