A Simple Computed Tomography Scoring System to Predict Histological Malignancy of Solitary Fibrous Tumors of the Pleura
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2015, Vol 5, Issue 10
Abstract
Purpose: The aim of the present study was to define the very first score enabling discrimination between benign and malignant solitary fibrous tumors of the pleura (SFTPs), on the basis of reliable preoperative CT features. Methods: Between December 2004 and November 2012, 56 patients underwent complete resection for SFTP at six institutes. CT scans were reviewed retrospectively, and a diagnostic scoring system for predicting malignant SFTP preoperatively was designed. Results: Univariate analysis revealed seven significant predictors of malignant SFTP: tumor size ≥ 10 cm (p=0.002), tumor heterogeneity spontaneously (p=0.019) or after contrast medium injection (p=0.029), existence of intratumoral fluid density areas (p=0.011), a pleural effusion (p=0.01), measurable (diameter >1 mm) intratumoral vessels (p=0.019), a hypervascular character (visible intratumoral vessels and/or intense enhancement) (p=0.001). A scoring system based on these seven CT features, each assigned 1 point, and with a cut-off of 4 points, could predict malignant SFTP with a specificity of 85% and a sensitivity of 48%. Conclusion: Our scoring system using seven CT features (tumor size ≥ 10 cm, tumor heterogeneity with or without contrast injection, intratumoral fluid density areas, pleural effusion, measurable intratumoral vessels, and a hypervascular character of the tumor) may be helpful for predicting histological malignancy of solitary fibrous tumors of the pleura.
Authors and Affiliations
Siegfried Hélage, Marie-Pierre Revel, Marco Alifano, Audrey Mansuet-Lupo, Dominique Vadrot
Keywords
Related Articles
- EP ID EP347201
- DOI 10.9734/BJMMR/2015/13958
- Views 104
- Downloads 0
Alkaline Phosphatase Isoenzymes and Leukocyte Alkaline Phosphatase Score in Patients with Acute and Chronic Disease: A Brief Review
Aims: To conduct a review of the literature concerning existing methods to detect alkaline phosphatase (ALP) in human serum and to examine the dietary factors that modulate ALP-intestinal isoenzyme (IAP) activity, in lig...
Health Professionals in the 21st Century: Results from an Inter Professional and Multi-institutional Global Health Competencies Survey (A Pilot Study)
Introduction: In the new century, worldwide health professionals face new pressures for changes towards more cost-effective and sustainable health care for all populations. Globalization creates daunting challenges as we...
A Simple Computed Tomography Scoring System to Predict Histological Malignancy of Solitary Fibrous Tumors of the Pleura
Purpose: The aim of the present study was to define the very first score enabling discrimination between benign and malignant solitary fibrous tumors of the pleura (SFTPs), on the basis of reliable preoperative CT featur...
Influence of Flaxseed on Some Biochemical Factors, Antioxidant Activity and Expression of ABCG5 and ABCG8 Genes in the Liver of Diabetic Rat
Aims: The aim of this experiment is to study the effect of flaxseed on lipid profile, antioxidant activity and ATP-cassette binding proteins G5 and G8 (ABCG5 and G8) levels in the liver of diabetic rat. Place and Durati...
Profile of Neurocognitive Impairment in Individuals Coinfected with Human Immunodeficiency Virus and Hepatitis C Virus: Meta-analysis and Meta-regression
HIV and HCV are neurotrophic viruses with great potential to cause neurocognitive impairments (NCI). Yet, results of neuro studies among Coinfected individuals are still inconclusive. This study pooled estimates to defin...