A Study of Acute Kidney Injury in Patients with Snakebite Envenomation
Journal Title: Journal of Medical Science And clinical Research - Year 2017, Vol 5, Issue 4
Abstract
Background and Objectives: Since long Snakebite-related acute kidney injury (AKI) is a common community-acquired AKI in tropical countries leading to death and disability. The aims of this study were to (1) determine the occurrence of snakebite-related AKI, (2) assess factors at presentation that are associated with snakebite-related AKI, and (3) determine the outcomes of patients with snakebiterelated AKI. Methods: We conducted a prospective observational study of patients with snake envenomation at our tertiary hospital during the calender year of 2016. Patient data including baseline characteristics, clinical and laboratory findings, hospital management, and outcomes were recorded in a case report form. A stepwise multivariate logistic regression analysis using a backward selection method determined independent factors significantly associated with AKI. Results: AKI was observed in 140 patients (54.3%), the majority of whom were AKI stage III (110 patients, 78.6%). AKI occurred at presentation and developed during hospitalization in 88 (62.9%) and 52 patients (37.1%), respectively. Twenty-seven patients died (19.3%), and 69 patients (49.3%) required dialysis. On multivariate logistic regression analysis, (1) snakebites from the Viperidae family (odds ratio [OR]: 9.65, 95% confidence interval [CI]: 2.42–38.44; p = 0.001), (2) WBC >10 × 103 cells/μL (OR: 3.55, 95% CI: 1.35–9.34; p = 0.010), (3) overt disseminated intravascular coagulation (OR: 2.23, 95% CI: 1.02–4.89; p = 0.045), (4) serum creatine kinase >500 IU/L (OR: 4.06, 95% CI: 1.71–9.63; p = 0.001), (5) serum sodium <135 mmol/L (OR: 4.37, 95% CI: 2.04– 9.38; p < 0.001), (6) presence of microscopic hematuria (OR: 3.60, 95% CI: 1.45–8.91; p = 0.006) Conclusions: If we dentify factors associated with snakebite-related AKI might help clinicians to be aware of snakebite patients who are at risk of AKI, particularly patients who demonstrate renal tubular dysfunction after Viperidae bites.
Authors and Affiliations
Pranay Gandhi
Keywords
Related Articles
- EP ID EP281404
- DOI -
- Views 83
- Downloads 0
Prevalence of Anemia among Adolescent Girls in Rural Population of Rajnandgaon, Chhattisgharh, India
Introduction: The prevalence of under nutrition and anemia among adolescent girls is alarmingly high in India. Adolescent girls are at a greater risk of reproductive morbidity and mortality. To reduce the burden of anemi...
The incidence of differentiated carcinoma thyroid as histopathologic surprise in FNAC proved benign thyroid nodules
Background: The main role of fine needle aspiration cytology (FNAC) lies in differentiating between a malignant and benign thyroid nodule. It greatly influences the treatment decision. The current study was undertaken to...
Dermatosis in New Born a Clinical Study
There are few studies on new born dermatosis in our country. The aim of present study is to know the incidence of cutaneous changes in our area. Influence of Sex, birth weight and duration of gestation on early neonatal...
A Topical Cream Containing Niacinamide 4% and Gluconolactone 14% Modifies the Local C. Acnes Population in Patients with almost no or Mild Facial Acne
Background: C. acnes is involved in acne. Aim: To assess the evolution of C. acnes phylotypes,the antimicrobial activity, the risk for inducing antibiotic resistance emergence and the clinical efficacy of a cream contain...
Hysteroscopic Removal of Intrauterine Fetal Bones: Indian Scenario
The incidence of retained fetal bones is unknown. Most of the women present with secondary infertility and history of previous abortion. Previously, these were removed by dilatation and removal with ovum forceps but now...