A Study of Correlation of Pre-operative Serum CA-15.3 with Respect to Prognostic Factors and Early Recurrence in Breast Carcinoma in A Tertiary Care Centre in India
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 10
Abstract
Introduction: There is a huge list of prognostic markers in breast cancer but the availability of a circulating prognostic factor, which is cost effective, especially fit to provide independent data and was prognostic would be of value in breast cancer. The study was aimed to correlate serum CA 15.3 levels at the time of presentation with various other prognostic markers like tumour size, Nodal status, TNM staging, ER,PR and Her2/neu status, HPE report of tumour metastasis, early recurrence within one year and whether it can be used as a prognostic marker, indicator for tumour aggressiveness and recurrence . Material and methods: It was an institution based, prospective observational study in a tertiary care centre. Study was conducted on patients who attended the department of General Surgery at Medical College Kolkata. The Pearson correlation test was used to examine association between parametric variables and Serum CA 15.3 levels and Spearman’s Rank Correlation test was applied to check association of all nonparametric variables. Results: Serum CA 15.3 Levels correlated highly significantly with size of breast tumor, metastasis and clinical staging and significantly and with T-Stage and Nodal Status all having a positive correlation. Serum CA 15.3 Levels also correlated highly significantly with histological Grade and lymphovascular invasion and recurrence at one year with a positive correlation. Serum CA 15.3 levels however had negative correlation with age of the patient. Conclusion: CA 15.3 can be used as diagnostic and prognostic marker in the most common carcinoma i.e ductal carcinoma of breast.
Authors and Affiliations
Chandan Roy Choudhury, Neha Choudhary
Keywords
Related Articles
- EP ID EP432562
- DOI -
- Views 131
- Downloads 0
Diagnostic Role of CSF-ADA in Differential Diagnosis of Meningitis
Introduction: Among the patients with meningitis, tubercular meningitis is an important cause of morbidity and mortality in India and other developing countries. Due to lack of early diagnosis, fatality is high in positi...
Screening of Cervical Cancer by Artificial Intelligence based Analysis of Digitized Papanicolaou-Smear Images
Introduction: Cervical cancer is one of the main causes of female mortality due to cancer in the world. Researchers have suggested that by regular cervical cancer screening its incidence and mortality a can be reduced by...
Palatal Schwannoma: A Rare Case Report
Introduction: Schwannomas are benign encapsulated perineural tumors. The head and neck region is the most common site. Intraoral origin is seen in only 1% of cases, tongue being the most common site; its location in the...
Observation on Symptoms Persisting after Laparoscopic Cholecystectomy
Introduction: Laparoscopic cholecystectomy which is most widely practiced for symptomatic gallstones has gained tremendous popularity over the last three decades. A substantial amount of patients presenting with persisti...
Patient’s Awareness and Knowledge of the Root Canal Treatment in Kashmiri Population: A Survey-based Original Research
Introduction: Root canal treatment (RCT) is one of the most common endodontic procedures for which patient visits the dentist. Patients’ awareness and knowledge of the endodontic treatment is a very important issue in ev...