A Study of High Sensitivity C - reactive Protein in Cerebrovascular Accident
Journal Title: Journal of Advances in Medicine and Medical Research - Year 2016, Vol 18, Issue 4
Abstract
Background: Inflammation plays an important role in the pathogenesis of stroke. C-reactive protein (CRP) is the most reliable marker of inflammation. Cerebrovascular accident is the second most common cause of death in the world causing about 5 million deaths in a year. High sensitivity CRP (hsCRP) refers to lower detection limits of assay procedure being used (1 mg/L). High levels of hsCRP in stroke indicates poor prognosis. Objectives: The objectives of the study are to observe the levels of hsCRP in cerebrovascular accident, the role of hsCRP in differentiating ischemic and hemorrhagic stroke, the relation between the levels of hsCRP and the size of the lesion and the outcome of patients with stroke in relation to hsCRP. Methodology: Fifty patients with first episode of stroke as evidenced by CT scan, presenting to the Department of General Medicine, SVRRGG Hospital, Tirupati from August 2013 to August 2014 are studied and the levels of hsCRP are measured and analyzed. Results: In the study, majority of the patients (58%) are in the age group of 56-70 years with a male preponderance. Hypertension (62%) is the commonest risk factor observed followed by smoking (40%) and diabetes (36%). Most of the study population (96%) has raised hsCRP levels. Mean hsCRP (in mg/L) is high in patients with large (>3 cm) infarcts (53.51±18.13) compared to those with small (<3 cm) infarcts (8.71±6.27). In hemorrhagic stroke, mean hsCRP is high in patients with large (32.11±28.11) bleeds than those with small bleeds (12.90±11.14). In both ischemic and hemorrhagic stroke non survivors have hsCRP levels higher than survivors and the levels correlate with GCS score. Conclusion: hsCRP is raised in both ischemic and hemorrhagic stroke. The rise in hsCRP is less in small lesions compared to that of large lesions and the levels are high in diseased than in survivor group.
Authors and Affiliations
C. Jayabhaskar, M. Ramadevi, N. Sreelalitha
Keywords
Related Articles
- EP ID EP340892
- DOI 10.9734/BJMMR/2016/27012
- Views 82
- Downloads 0
Combined Intestinal Ischemia, Cerebral Stroke and Thrombosis of Thoracoabdominal Aorta and Splenic Artery in a Thrombophilic Woman: A Case Report
Aim: To present an uncommon, life-threatening case of intestinal ischemia complicated by cerebral stroke, thoraco-abdominal aorta and splenic artery thrombosis, in a woman with thrombophilia presenting common clinical si...
A Novel High-strength GIC System Composed of Poly (Acrylic Acid) With Different Molecular Architectures
Aims: The objective of this study was to synthesize and characterize the poly (acrylic acid) or PAA with different molecular architectures, use these polymers to formulate the cements with glass fillers, and evaluate the...
Isolated Unilateral Adduction Paresis of the Right Eye Due to a Contusion in the Subnucleus of Oculomotor Nerve
In this report we present a 45 year old man with horizontal diplopia following minor head trauma. Neurological examination was normal except for unilateral adduction paresis of the right eye. Brain magnetic resonance ima...
High-dose and Long-term Users of Hypnotic and Sedative Drugs among Taiwanese Outpatients: Prevalence and Correlates from a Population-based Analysis
Aims: This study aims to analyze the dose and length of hypnotic and sedative drug prescriptions under a free-to-visit health insurance system. Study Design: Outpatients aged 15 years and older covered by the Taiwan Nat...
Lung Function in Sudanese Children and Adolescents with Type 1 Diabetes Mellitus
Background: Diabetes Mellitus Type 1 (DMT1) is a chronic, debilitating and multifactor disease that is emerging as an important health problem in Sudan. The aim of this study was to investigate the lung functions in Suda...