A Study of Prognostic Indicators in Patients of Severe Falciparum Malaria on Treatment with Artesunate And Quinine
Journal Title: Scholars Academic Journal of Pharmacy - Year 2016, Vol 5, Issue 2
Abstract
Severe falciparum malaria is a common and fatal malarial illness. The recommended regimen for severe falciparum malaria includes either artesunate or quinine based treatment. 100 patients of severe falciparum malaria were divided into two groups and randomly assigned to either ARTESUNATE or QUININE based regimen. A detailed clinical and biochemical evaluation of both groups was compared. Most common clinical signs were pallor, icterus, hepatosplenomegaly, altered sensorium and decreased urine output. 30% of patients had GCS <11, 87% had serum lactate >5mmol/L, S. Bilirubin was raised in 50% but abnormal AST/ALT was found in all patients and equally distributed in both groups. Of the two regimens hypoglycemia during treatment was more common in QUININE group than ARTESUNATE group (30% vs 12%), there was also increased mortality in quinine group (13 vs 7) but was not statistically significant. However, mean hemoglobin rise, normalization of GCS, LFT, time to death and coma recovery time were no different in two groups. Among the quinine treated patients there was an increased incidence of hearing disturbances (24%), QT interval prolongation (6%), ARF (4%) and visual disturbance was present in one patient. Keywords: GCS, AST/ALT, LFT, GBP, KFT, ABG, PT, APTT, CRT.
Authors and Affiliations
Dr. Shivendra Verma, Dr. Richa Giri, Dr. Rajendra Verma, Dr. Vaibhav Srivastav, Dr. Saumya Gupta
Keywords
Related Articles
- EP ID EP377451
- DOI -
- Views 118
- Downloads 0
Formulation and Evaluation of Immediate Release Tablets of Zaltoprofen
Zaltoprofen is a nonsteroidal anti-inflammatory drug (NSAIDs) with powerful analgesic action on inflammatory pain. The purpose of this research work was to formulate an immediate release tablet of Zaltoprofen for the tre...
Study of Callicarpa macrophylla Leaves as Hepatoprotective in Wistar Rats
Abstract: Liver is one the most important organ, which plays a provital role in regulating various physiological processes in the body. It has great capacity to detoxicate toxic substances and synthesize useful principle...
Development and Validation of RP-HPLC Methods for the Estimation of API’s in Newanti Injection and Restozeal Tablets
Newanti injection comprises of 0.3 mg Biapenem in powder for injection, used as in vitro agent against anaerobes. Resveratrol is an antioxidant in Restozeal tablets. Since HPLC methods were more accurate, precise and sen...
Role of Medicinal Plants in the Treatment of Alzheimer’s Disease: A Review
Abstract: Alzheimer’s disease (AD) is an age related neuro degenerative disorder that is characterized by a progressive loss of memory and deterioration of higher cognitive functions. The brain of an individual wit...
Pattern of Utilization of Anticancer Medications at a Tertiary Care Hospital in South-South Nigeria
Globally, cancer constitutes a major cause of morbidity and mortality with increasing incidence and prevalence. Drug utilization studies promote rational use of drugs. This retrospective, observational and descriptive st...