A STUDY ON CASES OF PANCYTOPENIA WITH EVALUATION OF VARIOUS CLINICAL SYMPTOMS AND AETIOLOGIES
Journal Title: Journal of Evidence Based Medicine and Healthcare - Year 2018, Vol 5, Issue 30
Abstract
BACKGROUND Several diseases can cause bone marrow failure, resulting in greatly reduced to absent haematopoiesis with subsequent pancytopenia. Pancytopenia which includes deficiency of all three cellular elements of blood resulting in anaemia, leucopoenia and thrombocytopenia is a common haematological entity that we have come across in routine practice. Hence a detailed clinical examination, thorough haematological investigation and bone marrow study of patients usually helps in identification of the underlying cause and adds to the pathologist’s role as a consultant to the patient’s treating physician. MATERIALS AND METHODS The study included 100 consecutive cases (both adult and children) with peripheral pancytopenia in the department of haematology (pathology) at SCB MC, Cuttack from January 2017 to April 2018. Patients receiving chemotherapy/radiation were excluded. Apart from detailed clinical examination, complete blood count, peripheral smear examination and bone marrow study (aspiration/trephine biopsy) were conducted. This was a cross sectional study. RESULTS The 100 consecutive cases showed a male predominance (58%). Most common clinical presentation was generalised weakness followed by fever. Most common cause for pancytopenia in adults was aplastic anaemia (40%) and acute leukaemia in children (60%). This was closely followed by Megaloblastic Anaemia (36%) whereas aplastic anaemia (40%) was second most common cause for pancytopenia among paediatric age group. Other causes included MDS with excess blast and hypersplenism. CONCLUSION Out of 100 consecutive cases, aplastic anaemia was most common cause of pancytopenia closely followed by megaloblastic anaemia in adults; whereas in paediatric cases, acute leukaemia was the most common cause followed by aplastic anaemia. The role of bone marrow study along with detailed clinical and haematological evaluation plays a very important role.
Authors and Affiliations
Priyadarshini Biswal, Dilleswari Pradhan, Asaranti Kar, Akhyaya Kumar Dash, Dharitri Mohanty
Keywords
Related Articles
- EP ID EP570012
- DOI 10.18410/jebmh/2018/458
- Views 83
- Downloads 0
A STUDY ON HEPATIC DYSFUNCTION IN DENGUE FEVER
BACKGROUND Dengue fever is a public health problem in India like many other countries. It causes epidemics almost each year in different parts of India causing a burden to our healthcare system. Apart from the classical...
ENZYMATIC CHANGES IN SNAKE ENVENOMATION- AN OBSERVATIONAL STUDY
Snakes are the most feared and the most worshipped living creatures on the earth. Snakes are called venomous when envenomation or human fatalities after their bite are known. Snakebite is an acute medical emergency faced...
STUDY OF EVALUATION OF RISK FACTORS OF ACUTE MYOCARDIAL INFARCTION WITH SPECIAL REFERENCE TO VITAMIN D STATUS- A CASE CONTROL STUDY, DONE AT A TERTIARY CARE HOSPITAL OF TRIPURA
BACKGROUND Acute Myocardial Infarction (AMI) is a leading cause of morbidity and mortality globally. Efforts are always there to identify predisposing risk factors associated with development of AMI so that preventive ap...
ROLE OF ULTRASOUND IN MANAGEMENT OF BLUNT ABDOMINAL TRAUMA
BACKGROUND Blunt abdominal trauma is one of the most common causes of death in young population. It is a diagnostic challenge, even to the experienced surgeons. Timely management is very important to prevent death due to...
STUDY OF CORROSIVE POISONING AND ITS EFFECTS ON UPPER GASTROINTESTINAL TRACT AND SURGICAL MANAGEMENT- A SINGLE INSTITUTION EXPERIENCE
BACKGROUND Corrosive injury to the upper gastrointestinal tract is an agonising experience for both the patient and surgeon. Caustic ingestion may cause wide spread injury to the lips, oral cavity, pharynx and the upper...