A STUDY ON THE PREVALENCE AND SEVERITY OF POSSIBLE DRUG-DRUG INTERACTIONS IN PEDIATRICS DEPARTMENT AT AN INDIAN TERTIARY CARE TEACHING HOSPITAL
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 10, Issue 7
Abstract
Objective: To study the prevalence and severity of possible drug-drug interactions in the department of pediatrics.Methods: Case records of the in-patients of the pediatrics department from the medical records department were included and the records of the ambulatory patients were excluded from the study. All the collected cases were subjected to check for the drug-drug interactions by using the software micromedex 2.0 and the interactions were categorized based on the severity into minor, moderate and major.Results: A total of 142 cases were screened for possible drug-drug interactions (DDIs) and among them 76 cases were observed to be with possible DDIs. The prevalence was found to be 53.5% in this study. Majority of the cases with possible DDIs were observed to be in females. Results of the age wise categorization revealed that majority of the possible DDIS were observed in children (2-12 y) followed by the infants (1 mo–2 y). The drug combinations amikacin+ampicillin, paracetamol+phenytoin and ofloxacin+ondansetron were found to be the frequently observed possible DDIs of minor, moderate and major severities respectively.Conclusion: Majority of the possible DDIs were of moderate severity followed by major. Clinical pharmacists should take the responsibility in assisting the pediatricians for screening the possible DDIs in the prescriptions there by preventing them and providing a better pharmaceutical care for the pediatric population. Â
Authors and Affiliations
Ramam Sripada, S. V. Suresh Kumar, N. Devanna, Kandula Ravindra Reddy
Keywords
Related Articles
- EP ID EP566217
- DOI 10.22159/ijpps.2018v10i7.27183
- Views 66
- Downloads 0
CINNAMOMUM GENUS: A REVIEW ON ITS BIOLOGICAL ACTIVITIES
The objective of this review is to systematically appraise the literature available to date on biological activities (in vitro and in vivo) of extracts and constituents from Cinnamomum. An extensive review of the literat...
EFFECT OF ETHANOLIC EXTRACT OF GLYCYRIZZA GLABRA AGAINST STEREPTOZOTOCIN AND HIGH FAT DIET INDUCED DIABETES AND HYPERLIPIDEMIA
Objective: To study the effect of ethanolic extract of Glycyrrhiza glabra against streptozotocin and high-fat-diet-induced diabetes and hyperlipidemia.Methods: The present study was conducted on a 14 d model in which Gly...
STUDY OF CNS ACTIVITIES OF PIPERINE PERSE AND ITS BIOENHANCING EFFECT ON VARIOUS DRUGS IN EXPERIMENTAL ANIMAL MODELS
Objective: Study of CNS activities of piperine perse and its bio-enhancing effect on various drugs in experimental animal models.Methods: The CNS effects of piperine and its interaction with various drugs were evaluated...
SIMULTANEOUS DETERMINATION OF ARTESUNATE AND AMODIAQUINE IN HUMAN PLASMA USING LC-MS/MS AND ITS APPLICATION TO A PHARMACOKINETIC STUDY
Objective: The objective of this research was to develop a simple, rapid and sensitive liquid chromatography/tandem mass spectrometry (LC-MS/MS) method for the simultaneous quantification of artesunate and amodiaquine in...
IMMUNOMODULATORY ACTIVITY OF INDIGOFERA TINCTORIA LEAF EXTRACT ON IN VITRO MACROPHAGE RESPONSES AND LYMPHOCYTE PROLIFERATION
Objective: In this study the effects of ethanolic and aqueous extracts of Indigofera tinctoria were investigated on the functions of peritoneal macrophages and peripheral blood lymphocytes isolated from Wistar rats throu...