A STUDY ON THE PREVALENCE AND SEVERITY OF POSSIBLE DRUG-DRUG INTERACTIONS IN PEDIATRICS DEPARTMENT AT AN INDIAN TERTIARY CARE TEACHING HOSPITAL
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2018, Vol 10, Issue 7
Abstract
Objective: To study the prevalence and severity of possible drug-drug interactions in the department of pediatrics.Methods: Case records of the in-patients of the pediatrics department from the medical records department were included and the records of the ambulatory patients were excluded from the study. All the collected cases were subjected to check for the drug-drug interactions by using the software micromedex 2.0 and the interactions were categorized based on the severity into minor, moderate and major.Results: A total of 142 cases were screened for possible drug-drug interactions (DDIs) and among them 76 cases were observed to be with possible DDIs. The prevalence was found to be 53.5% in this study. Majority of the cases with possible DDIs were observed to be in females. Results of the age wise categorization revealed that majority of the possible DDIS were observed in children (2-12 y) followed by the infants (1 mo–2 y). The drug combinations amikacin+ampicillin, paracetamol+phenytoin and ofloxacin+ondansetron were found to be the frequently observed possible DDIs of minor, moderate and major severities respectively.Conclusion: Majority of the possible DDIs were of moderate severity followed by major. Clinical pharmacists should take the responsibility in assisting the pediatricians for screening the possible DDIs in the prescriptions there by preventing them and providing a better pharmaceutical care for the pediatric population. Â
Authors and Affiliations
Ramam Sripada, S. V. Suresh Kumar, N. Devanna, Kandula Ravindra Reddy
Keywords
Related Articles
- EP ID EP566217
- DOI 10.22159/ijpps.2018v10i7.27183
- Views 82
- Downloads 0
IDENTIFICATION OF NOVEL INHIBITORS AGAINST POTENTIAL TARGETS OF CAMPYLOBACTER JEJUNI
Objective: The aim of the present study is the structure identification of UDP-N-acetyl muramate dehydrogenase and 4-hydroxy-3-methylbut-2-enyl diphosphate reductase for Campylobacter jejuni and designing their inhibitor...
DESIGN, SYNTHESIS AND IN VITRO ANTI-CANCER ACTIVITY OF NOVEL 1,2,4-TRIAZOLE DERIVATIVES
Objective: DNA topoisomerase is one of the important targets for anticancer agents. Many triazole derivatives have been shown to possess cytotoxic activity. In this paper, we present the design and in silico docking of a...
MOLECULAR ANALYSIS OF THE CAMP- RESPONSE ELEMENT [CRE] ELEMENTS IN THE PROMOTER REGION AND EXON 1 OF THE SURVIVAL OF MOTOR NEURON 2 [SMN2] GENE IN MALAYSIAN SPINAL MUSCULAR ATROPHY PATIENTS; TO ELUCIDATE THEIR ROLE IN CIRCUMSCRIBING THE CLINICAL SEVERITY
Objective: In the Spinal muscular atrophy [SMA] genes [SMN1 and SMN2 genes]; the CRE-II elements at -400 bp in the promoter region of the SMN genes and CRE-I element at +108 bp in the exon 1 of the SMN genes, are reporte...
EFFECT OF COMBINATION OF TWO PLANT EXTRACTS ON DIABETES MELLITUS
Objective: To investigate the anti-diabetic activity of combined ethanolic extracts (1:1mixture) of dry leaves of Syzygium cumini and Psidium guajava belonging to the family Myrtaceae as well as to compare the anti-diabe...
GREEN SYNTHESIS OF SILVER NANORODS USING AQUEOUS EXTRACT OF KALANCHOE PINNATA FRESH LEAVES AND ITS SYNERGISTIC EFFECT WITH CIPROFLOXACIN AND ANTIBIOFILM ACTIVITIES
Objective: The present study was aimed to investigate antibacterial and antibiofilm activities of AgNPs alone and its combination with ciprofloxacin against various human pathogenic bacteria strains.Methods: Reproducible...