A Study to Evaluate Proconvulsive Effect of Ofloxacin in Mice
Journal Title: Scholars Academic Journal of Pharmacy - Year 2016, Vol 5, Issue 2
Abstract
The study was carried out to evaluate Proconvulsive effect of ofloxacin on electro convulsion & chemo convulsion and also to see its effect on locomotor activity in mice. The animals were given either saline (0.2 ml) or ofloxacin (25 mg/kg) intraperitoneally (i.p.) and the effect on spontaneous locomotor activity and maximal electroshock induced seizures (MES) was recorded. The mice were also given single & multiple doses of saline (0.2 ml i.p) or ofloxacin (25 mg/kg i.p.) and then they were subjected to sub convulsive doses of pentylenetetrazole (40 mg/kg i.p.) or picrotoxin (1 mg/kg i.p.) or strychnine (0.5 mg/kg i.p.). In results-the ofloxacin did not change the spontaneous locomotor activity or duration of tonic extension of hind limb of MES induced seizure significantly as compared to control group. Mortality was more in ofloxacin group after MES than the control group (30% vs 20%). No convulsions or jerky movements were seen after giving convulsants during single as well as multiple dose studies. Also no deaths were seen during subsequent 24 hours. The results indicate that ofloxacin may not have proconvulsant effect although higher doses of ofloxacin or other fluoroquinolones may be having this kind of adverse effects. Keywords: Fluoroquinolones, convulsion, locomotor activity, Maximal electroshock seizure.
Authors and Affiliations
Kurle DG, Bagle TR, Satpute SM, Deshmukh YA
Keywords
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