A study to find correlation of Vitamin D level with Disease Activity Measured by DAS 28 Score In Rheumatoid Arthritis Patients
Journal Title: IOSR Journal of Dental and Medical Sciences (IOSR-JDMS) - Year 2019, Vol 18, Issue 3
Abstract
Introduction: Rheumatoid arthritis is an immune-mediated disease, mainly driven by Th1 cells. Prevalence of RA is approximately 0.8% of population (range 0.13-1.2%). Overall prevalence of RA is three times higher in women than in men Vitamin D may have a role in Rheumatoid arthritis because it suppresses Th1 cells which are a part of adaptive immunity. Data obtained from animal models show that the VDR ligand along with other factors may control the development of RA 5 .Due to possible role of vitamin D in development of RA and its severity, we conducted this study to find out correlation between rheumatoid arthritis disease activity and serum Vitamin D level .Material and methods: Hospital based case control type of analytical study of 80 cases of Rheumatoid arthritis and 80 controls studied based on detailed history, examination, blood investigations,DAS 28 score.Results: In our study there was significant negative correlation between disease activity measured by DAS-28 in RA and serum 25(OH) Vitamin D level (p<0.05) Conclusion: The result of our study showed that In Rheumatoid arthritis, disease activity measured by DAS-28 is inversely related to Vitamin D level. So timely vitamin d supplementation to patients can reduce inflammatory burden.
Authors and Affiliations
Dr. Dharam. P. Bansal, Dr. Pradeep Kumar sharma, Dr. Venus Sharma, Dr. Arpit Pareek, Dr. Piyush
Keywords
Related Articles
- EP ID EP554068
- DOI 10.9790/0853-1803027380.
- Views 57
- Downloads 0
Outcomes of Thoracoscopic Thymectomy in Children: Experience in A Resource Challenged Setup
Thoracoscopic thymectomy which has a steeper learning curve is now becoming a reality in many centers in developing countries. The aim of the study is to highlight the advantage of thoracoscopic thymectomy over conventio...
Assessment of Adverse Drug Reaction’s From The Treatment Charts of A Hospitalised Patients Suffering With Cardiac Arrhythmias And Complications Due To Adverse Drug Reaction’s
Cardiac Arrhythmia is a condition in which the heart’s normal rhythm is disrupted. The heart may beat too slowly, too quickly or with an irregular rhythm. Most arrhythmias are harmless, but some can be serious and potent...
Difficult DJ stent Removal - Our Experience and Evolution of Institutional Protocol for Management of Stuck DJ stent
Introduction :Stent removal is a routinely done urological procedure and at times we encounter difficulty in stent removals. It is important to follow careful plan of action to avoid complication. Our objective is to mak...
A Correlation Analysis for Estimation of Height from Head Breadth and Vertex Height
Stature can be expressed as stable proportional relationship with other body part measurements of the human body like head, face, trunk and extremities etc. Study was conducted to estimate a correlation between Height ag...
Nerve Conduction Studies in Leprosy- A Review.
Leprosy involves peripheral nerves sooner or later in the disease course leading to gross deformities. However, by the time it becomes clinically apparent, the nerve damage is already quite advanced. If the preclinical d...