A VALIDATED RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF FLUOXETINE HYDROCHLORIDE AND OLANZAPINE IN PHARMACEUTICAL DOSAGE FORM
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
A simple, sensitive and precise reverse phase high performance liquid chromatographic method has been developed for the simultaneous estimation of Fluoxetine hydrochloride and Olanzapine in pharmaceutical dosage forms. The mobile phase consisted of Acetonitrile: pot.dihydrogen phosphate buffer: Triethylamine (0.2 %) (0.1% v/v ortho phosphoric acid, PH 3.1) in the ratio of 40:60:0.2 v/v/v delivered at a flow rate of 1.0 ml / min and wavelength of detection at 233 nm. The retention times of Fluoxetine and Olanzapine were 1.96 min and 5.59 min respectively. The developed method was validated according to ICH guidelines. The proposed method can be used for determination of these drugs in combined dosage forms.
Authors and Affiliations
M. M. Eswarudu, M. Anitha, N. Gayathri, T. Chaithanya
Keywords
Related Articles
- EP ID EP124886
- DOI -
- Views 109
- Downloads 0
EVALUATION OF ANTI-INFLAMMATORY ACTIVITY AND ANALGESIC EFFECT OF ALOE VERA LEAF EXTRACT IN RATS
Clinical evaluation of analgesic and anti-inflammatory drugs envisages the development of side effects that makes efficacy of a drug arguable. Alternatively, indigenous drug with fewer side effects is the major thrust ar...
MENTAL HEALTH CHALLENGES AND POSSIBLE SOLUTIONS WITH SPECIAL REFERENCE TO ANXIETY
Mental disorders are universal and very common. No country can postpone service development until the finalization of national level epidemiological surveys. It should be noted also that such surveys are very costly and...
ROLE OF COPPER AND IRON DEFICIENCIES IN PATHOGENESIS OF RECURRENT APHTHOUS ULCER
The aim of the study was to estimate the serum levels of copper and iron in recurrent aphthous ulcer (RAU) patients and to compare these levels with normal healthy individuals. A total of 60 patients were examined with 3...
SACCHARIFICATION BY FUNGI AND ETHANOL PRODUCTION BY BACTERIA USING LIGNOCELLULOSIC MATERIALS
Lignocellulosic material is one of the most abundant, renewable and inexpensive energy resources for bioethanol production. These materials are mainly composed of three groups of polymers namely cellulose, hemicellulose...
KINETICS OF OXIDATION OF SALBUTAMOL BY CHLORAMINE-B IN NaOH MEDIUM: A MECHANISTIC APPROACH
The kinetics of oxidation of salbutamol (SBL) by N-chlorobenzenesulphonamide (CAB) in NaOH medium has been investigated at 303K. The reaction rate shows a first order dependence on [CAB]0 , fractional order with resp...