Accuracy of admission Torniquet test in the diagnosis of early stage of dengue infection as compared with NS1 antigen
Journal Title: Medpulse International Journal of Pediatrics - Year 2019, Vol 10, Issue 1
Abstract
Objective: To determine the accuracy of the admission tourniquet test in the diagnosis of early stage of dengue infection as compared with NS1 antigen. Design: A prospective cross-sectional study design. Setting: Tertiary Government Hospital in Quezon City Participants: Subjects included children 6 months to 18 years of age admitted for fever of five days or less. Tourniquet test was done simultaneously with NS1antigen on admission. Main outcome measure: Accuracy of tourniquet test as compared with Ns1 antigen was determined through sensitivity, specificity, predictive value, likelihood ratio and Receiver Operator Curve. Result: Four hundred subjects were enrolled in the study. The prevalence of dengue infection in this study is 56.25% (95%CI 51.23, 61.17). The overall accuracy of tourniquet test relative to NS1ag is 81.30% (95% CI 77.13 - 84.77%). The sensitivity of tourniquet test using NS1 antigen as the gold standard was 88.89% (95% CI 84.04%, 92.68%); its specificity was 71.43% (95% CI 64.12%, 77.99%). The positive predictive value of tourniquet test as compared with NS1antigen was 80.00% (95%CI 74.50%, 84.78%), its negative predictive value was 83.33% (95% CI 76.39%, 88.91%). The positive likelihood ratio of tourniquet test relative to NS1antigen is 3.11 (95%CI 2.45, 3.95) with a negative predictive value of 0.16 (95% CI 0.11, 0.23). The Area Under the Curve is 0.804 (95%CI 0.76, 0.84). Conclusion: The tourniquet test is a simple, accurate and readily available diagnostic test for dengue infection. The accuracy of admission tourniquet test is comparable with NS1 antigen.
Authors and Affiliations
Deepraj U Adhikari, Triza C Baliuag
Keywords
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- EP ID EP539372
- DOI 10.26611/10141016
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