Acquired Hemoglobin Disorders
Journal Title: Chettinad Health City Medical Journal - Year 2017, Vol 6, Issue 2
Abstract
Hemoglobin is made of Heme and globin and disorders of hemoglobin can be due to abnormality in either one of them. More than 1000 genetic mutations have been identified to cause hemoglobin disorders. Mutations can affect heme molecule and cause disorders like Methemoglobinemia. Mutations affecting globin chains are called Hemoglobinopathies and can be quantitative (thalassemia) or qualitative (sickle cell Anemia) .Hemoglobin disor- ders are mostly inherited and only a few are acquired. In this article we discuss about the structure of heme and globin molecules, abnormalities that can occur in them and review about Acquired Heme and Globin disorders. Acquired heme disorders are Methemoglobinemia and Sulfhemoglobinemia and an example for acquired globin disorder is alpha thalassemia.
Authors and Affiliations
Vigneshwaran J, Thuvaragah P, Gorgya S
Keywords
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