Adipokines-AMPK Cross-Talk in Avian Species: A Translational Model for Human Obesity
Journal Title: Obesity Research - Open Journal - Year 2016, Vol 3, Issue 2
Abstract
Adipocytokines, or adipokines, are circulating hormones mainly produced by adipose tissue and are key regulators of whole body metabolism and immune homeostasis. Due to a rise in human obesity-related diseases, pathways related to metabolism are being studied using several animal models to identify key molecular signatures for development of mechanism-based therapeutic strategies. Previous work published in our laboratory has used chickens as a model for obesity because of its peculiarities that will be described in this article. In particular, recent advances in our understanding of adipokine AMP-activated protein kinase (AMPK) interactions in the regulation of energy balance will be summarized as well as facilitating the discussion by asking new questions which may open new vistas for future research.
Authors and Affiliations
Alissa Piekarski-Welsher
Keywords
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- EP ID EP554254
- DOI 10.17140/OROJ-3-126
- Views 157
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