Adverse Drug Reactions Monitoring of Antimicrobials in ICU, Department of Medicine at a Tertiary Care Hospital, Rewa, MP
Journal Title: Scholars Journal of Applied Medical Sciences - Year 2018, Vol 6, Issue 10
Abstract
Adverse drug reaction (ADR) contributes to the burden of drug related patient morbidity, mortality and adding to the cost of patient health care. The aims of study is to assess the frequency & pattern of ADRs and the group of drugs commonly involved to producing the suspected ADRs in intensive care unit of medicine department. This study was conducted between August 2015 to July 2016. All cases that have suspected ADRs conform to WHO definition, having of age 18 years or more were enrolled in the study. Total 164 cases with suspected ADRs were presented during study. The data were analyzed by Microsoft word - excel version 2007. All the multiple responses were presented in terms of number and percentage. Total 4860 patients were admitted in medicine ICU during study period, out of which 2714 were males and 2146 were females. Maximum 49 (29.13%) patients with suspected ADRs were belong to ≥60 years of age and minimum 13 (6.08%) were belong to 30-39 years of age group. Gastrointestinal system is the most commonly (35.21%) involved organ system and nausea is most commonly (19.13%) reported ADR, followed by vomiting, diarrhea and skin rashes. Among antimicrobials Ceftriaxone was maximally (17.73%) associated with ADRs, followed by Levofloxacin (9.92%), Quinine and Metronidazole (7.8%). In our study the majority of patients were females. The gastrointestinal system is the most common affected organ system and the antimicrobials are the drugs having highest incidence of suspected ADRs, among AMAs Ceftriaxone is maximally associated with suspected ADRs.
Authors and Affiliations
Raj Bhupendra, Pandey Vivek, Singh Prabhakar, Dubey Vandana
Keywords
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