Abstract

: Swertiamarin, a secoiridoid glycoside is one of the major components and an active lead isolated from a perennial herb Enicostemma littorale (EL) Blume. Swertiamarin has been reported for its number of pharmacological activities namely, hepatoprotective, antiedematogenic/anti-inflammatory, free radical scavenging activity, antispastic activity, dyslipidemia, hypolipidemic effect and anti-hyperlipidemic effect. Thus, swertiamarin has the potential to be a successful drug candidate in the future in the treatment of various diseases. Isolation and characterization of the swertiamarin following a published procedure didn’t yield the reported purity. Considering the therapeutic importance of swertiamarin, there is a need for the development of an effective method for the compound in good yield and purity. This method involves column chromatography of a methanolic extract of dried whole plant powder material of Enicostemma littorale Blume for the isolation in pure form. Swertiamarin, as colorless crystals with a yield of 7.3%, 97.5% purity by HPLC- PDA analysis was isolated and characterized by MS, IR and 1H-NMR. Comparison was done with reported literature. The percentage yield and purity of isolated swertiamarin was improved by this method. © 2018 iGlobal Research and Publishing Foundation. All rights reserved.

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