Analgesic, pro and anti-inflammatory activities of Desplatsia dewevrei; Cytokine gene expression using Wistar rats and mice
Journal Title: UNKNOWN - Year 2018, Vol 7, Issue 2
Abstract
Objective: Painkilling potential of Desplatsia dewevrei methanol leaf extract was examined using the acetic acid-induced writhing and hot-plate tests. Materials & Methods: Acute anti-inflammatory effect was studied using xylene-induced ear edema and carrageenan induced paw edema models. Gene expression using RT-PCR method was used to query TNF-α, resistin and adiponectin in Wistar rats after a 3-day administration of Desplatsia dewevrei. Results: Desplatsia dewevrei extract significantly (p<0.05) decreased the number of writhes in mice at 30 mg/kg when compared to the control and Aspirin. In the hot plate induced pain test, 10 mg/kg of extract triggered comparable analgesic effect as morphine up to 2 hrs after drug administration. There was significant decrease (p<0.05) in xylene-induced ear oedema at 10 and 30 mg/kg doses of the extract with 80% and 30% when compared to control and dexamethasone. For Carrageenan-induced paw oedema in rats, 30 mg/kg elicited equal effect as indomethacin at 10 mg/kg respectively. The downward regulation/expression of TNF-α, resistin and adiponectin in contrast with control and the expression of beta-actin further indicates that Desplatsia dewevrei has both pro and anti-inflammatory activities. Conclusion: Desplatsia dewevrei methanol leaf extract is anti-inflammatory and elicits both peripherally and centrally analgesic effect.
Authors and Affiliations
Oghale Ovuakporie-Uvo, MacDonald Idu, Philip Obarisiagbon, Callistus Abode
Keywords
Related Articles
- EP ID EP588775
- DOI -
- Views 61
- Downloads 0
Antioxidant and antidiabetic activity of Phoenix pusilla Gaertn. unripe fruit extract in streptozotocin-induced sprague dawley rats
The fruit of Phoenix pusilla Garetn. has been used in herbal medicines, as it is sweet, sour, cooling and laxative, cardiotonic, aphrodisiac, carminative and roborant. The objective of the present study was to investigat...
Pharmacology of Xanthium species. A review
The genus Xanthium (Family Asteraceae) is represented by 25 species that are widely distributed in the world. Only a few species such as Xanthium strumarium and Xanthium spinosum, are studied for different pharmacologica...
Phytochemical profile and antimicrobial potential of methanolic extracts of bark and leaf of Quassia indica (Gaertn.) Nooteb.
The study comprises the results of phytochemical analysis and antimicrobial evaluation of extracts from bark and leaf of Quassia indica (Gaertn). Nooteb. – a medicinal plant used in traditional healing owing to its analg...
Comparison of antiaspergillar activity of extracts of Tectona grandis Linn according to two antifungal susceptibility testing
Plants used as antimicrobials in the treatment of infectious diseases in folk medicine are regularly evaluated in different Laboratories. And, the processes of evaluation of antifungal susceptibility are often different...
Anticonvulsant, Anthelmintic and Antibacterial activity of Lawsonia inermis
Lawsonia inermis L. is a branched glabrous shrub or small tree, cultivated for its leaves although stem bark, roots, flowers and seeds have also been used in traditional medicine. In the present study anticonvulsant, ant...