Analytical Method Development and Validation for Simultaneous Determination of Bisoprolol Fumarate and Amlodipine Besylate
Journal Title: Indo American Journal of Pharmaceutical Research - Year 2011, Vol 1, Issue 5
Abstract
A fast, robust RP-HPLC method was developed for simultaneous determination of Bisoprolol fumarate and Amlodipine besylate in tablets. The mobile phase was mixture of Methanol: Acetonitrile: 50mM Potassium dihydrogen phosphate buffer KH2PO4 (25:30:45 v/v) at pH 3.0 at 1 ml/min. The stationary phase was C18Intersil 4.6 x 150 mm (id). UV detection was performed at 267 nm.
Authors and Affiliations
Shrikrishna B. Baokar, Ritesh S. Erande, Surfraj G. Shaikh
Keywords
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