Anemia as Co-Morbidity in COPD: Comparative Study of Oxidant Anti-Oxidant Imbalance in Anemic and Non Anemic COPD Patients
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 6
Abstract
Introduction: COPD is slowly progressing chronic airway disease. It is known to be associated with co morbidities. Anemia is associated with chronic illnesses. Inflammation, oxidative stress and physical inactivity in COPD may contribute to anemia. The aim of the present study was to compare oxidant antioxidant imbalance in anemia and non anemic COPD patients. Material and Methods: 336 COPD patients were enrolled in the present study. They were divided into anemic (n=168) and non anemic (n=168) groups on the basis of hematological parameters namely MCV (femtolitres), MCHC (%) and Hb (gm/dl) using automated analyzer. Results: Overall the mean age of anemic and non anemic COPD group was 46.63±14.26 and 40.89±13.38 yrs respectively (p<o. oo1). Significant difference was found between mean Hb, MCV and MCHC between two groups. On the basis of severity of disease in anemic COPD group there was significant difference in Hb in mild, moderate and severe/very severe COPD group. Non significant differences were found in MCV, MCHC in same group. Similar results were found in non anemic mild, moderate, severe/very severe COPD groups. In both anemic and non anemic COPD groups significant difference was found in Hb and MCHC in both males and females. Conclusion: There is oxidant antioxidant imbalance which is more in anemic COPD patients. Anemia is present as co morbidity in COPD and it is likely to influence the therapeutic outcome of the disease. Presence of anemia negatively influences the quality of life of patients. Thus it is important to identify anemia in COPD patients.
Authors and Affiliations
Shah Mohammad Abbas Waseem, V K Srivastava, Rubeena Bano, Seema Singh, Homnath Dhunagana
Keywords
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