Intrathecal Clonidine as an Adjuvant to Hyperbaric Bupivacaine: A Dose - Response Study
Journal Title: International Journal of Contemporary Medical Research - Year 2018, Vol 5, Issue 1
Abstract
Introduction: Clonidine, an α2 agonist, prolongs the action of local anaesthetic and provides satisfactory postoperative analgesia when administered intrathecally. Study aimed to compare the effects between two doses of clonidine (30 and 60 μg) in terms of hemodynamic profile, duration of analgesia, sensory and motor blockade, when used intrathecally as an adjuvant to 2.5 ml of 0.5% hyperbaric bupivacaine. Material and Methods: In this prospective, randomised, double blind study, 80 patients of American Society of Anaesthesiologists (ASA) I or II, aged 18 – 55 years, undergoing lower abdominal or lower limb surgery lasting less than 180 minutes were included. Patients were divided into two groups of forty patients each and they received intrathecally, 2.5 ml of 0.5% hyperbaric bupivacaine and either 30 μg of clonidine (Group C30) or 60 μg of clonidine (Group C60). Total volume was made constant by adding normal saline. Haemodynamic parameters, duration of sensory and motor blockade and duration of analgesia were noted. A p value <0.05 was considered significant. Results: Both groups were comparable with respect to demographic profile and haemodynamic parameters. Duration of sensory block, motor block and analgesia were significantly prolonged in Group C60 as compared to Group C30. Conclusion: Addition of clonidine to hyperbaric bupivacaine increased the duration of spinal anaesthesia and post operative analgesia in a dose dependent manner with minimal adverse effects.
Authors and Affiliations
Sara Mary Thomas, Mary Verghese, Melchisedec .
Keywords
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