Nail Creatinine Measurement in Evaluation of Chronicity of Renal Failure
Journal Title: International Journal of Contemporary Medical Research - Year 2017, Vol 4, Issue 11
Abstract
Introduction: Renal failure is common indication for hospitalisation. Prognosis and management of renal failure depends on whether renal failure is acute or chronic especially when deciding need for permanent renal replacement treatment . So present study was done with the objectives to measure nail creatinine in CKD patients, to measure nail creatinine in AKI patients, to measure nail creatinine in normal subjects and to compare nail creatinine in AKI,CKD and normal subjects and assess utility in differentiating AKI and CKD. Material and Methods: 3 groups of subjects were selected after history physical examination and investigations. One group includes CKD patients, other AKI patients and third one with no renal co morbidities. Finger nail clippings are collected, stored and pulverized and aqueous extract is analyzed for creatinine using Jaffes reaction Results: 150 patients were included in the study . 50 patients each in CKD group, ARF group and normal renal functions were included. Mean nail creatiinine (mg/100g nail ) in control group was 29.92, in ARF patients 30.03, and in CKD patients was 59.40. Correlation with nail creatinine for other parameters of chronicity were correlated with low hemoglobin , low calcium, raised serum creatinine ,raised phosphate and uric acid and it was significant with p value of 0.01 . 48% of CKD patients had small kidney compared to AKI and normal subjects. Creatinine had significant strong positive correlation with serum creatinine ,phosphate and uric acid levels .Nail creatinine had significant strong negative correlation with hemoglobin and calcium. Conclusion: Nail creatinine is a cheap and noninvasive test which can be used to assess the chronicity of renal failure
Authors and Affiliations
Sahna E, Himamani S
Keywords
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