ANTI-ANXIETY EVALUATION OF EXTRACTS OF STIGMA MAYDIS (CORN SILK)
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 8
Abstract
Objective: The anxiolytic activity of petroleum ether, chloroform and ethyl acetate extracts of Stigma maydis was investigated by Elevated Plus Maze, Hole Board and Mirror Chamber Test.Methods: The study was conducted using elevated plus maze, whole board and mirror chamber test. Female Laca/Balb c was used to carry out the studies. In each experiment, animals were equally divided into five groups; control, given saline solution and Tween 80, standard given diazepam (2 mg/kg i. p.) and test groups were given 250, 500, 750 and 1000 mg/kg of petroleum ether, chloroform and ethyl acetate extracts of Stigma maydis. The data were subjected to analysis of variance by taking mean and standard error to the mean using Tukey’s post-hoc test.Results: In Elevated Plus Maze chloroform extract (750 and 1000 mg/kg) of Stigma maydis revealed increase in time spent in open arm, frequency and preference to open arm as compared to control, which was almost comparable to diazepam. In Hole Board test decrease in number of head dips as compared to control was observed. In Mirror Chamber Test, the decrease in latency, increase in time spent in the mirror chamber and frequency as compared to control was observed. All of the changes were statistically highly significant.Conclusion: From our results it can be concluded that the chloroform extract of Stigma maydis showed anxiolytic activity at the dose of 750 and 1000 mg/kg.Â
Authors and Affiliations
Devleen Kaur, Divneet Kaur, Navpreet Bains, Anuja Chopra, Poonam Arora
Keywords
Related Articles
- EP ID EP578342
- DOI -
- Views 58
- Downloads 0
A REVIEW ON BIOLOGICAL ACTIVITIES AND MEDICINAL PROPERTIES OF CLERODENDRUM INFORTUNATUM LINN
India has a great wealth of various naturally occurring herbal drugs which have great potential pharmacological and physiological activities. Since ancient times, several diseases have been treated by the administration...
DIRECT COST OF TREATMENT OF DIABETES MELLITUS TYPE 2 IN PAKISTAN
Objective: Diabetes is a serious illness. It is a key and growing threat to the health of the global world. The prime concern of this research was to estimate the cost-of-illness of type 2 diabetes in Karachi, a major me...
ANTIMICROBIAL POTENTIAL OF STREPTOMYCES CHEONANENSIS VUK-A FROM MANGROVE ORIGIN
Objectives: The aim of the present study was to isolate, characterize and evaluate the activity of compounds produced by Streptomyces cheonanensis VUK-A.Methods: Chemical examination of the secondary metabolites of the s...
PROTECTIVE APTITUDE OF BORASSUS FLABELLIFER ROOT EXTRACTS AGAINST PARACETAMOL-INDUCED LIVER TOXICITY AND MYCOBACTERIUM TUBERCULOSIS (H37 RV)
Objective: Borassus flabellifer is an doub palm tree, different parts of it have been using as food and in traditional medicine. The root parts (rhizomes) are used for phytochemical analysis and evaluation of hepatoprote...
SMEDDS TABLET: COMPATABILITY OF SOLID SMEDDS USING VARIOUS PHARMACEUTICAL TABLET EXCIPIENTS
Objective: There are many successful products on the market which are the culmination of the self-micro-emulsification lipid technology applications. Despite the importance of lipid-based formulations, these systems have...