SMEDDS TABLET: COMPATABILITY OF SOLID SMEDDS USING VARIOUS PHARMACEUTICAL TABLET EXCIPIENTS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2016, Vol 8, Issue 9
Abstract
Objective: There are many successful products on the market which are the culmination of the self-micro-emulsification lipid technology applications. Despite the importance of lipid-based formulations, these systems have some limitations including; stability, complexity during large scale manufacturing process and limited dosage forms to such as soft gelatin capsule. In order to overcome these limitations, the prospect of converting self-micro-emulsifying drug delivery systems (SMEDDS) into tablet dosage form was investigated in this study.Methods: A self-micro-emulsifying oil formulation representing type III A lipid class composed of glycerox 767HC/croduret 40 ss at ratios of (80/20) was converted into solid SMEDDS using solid carrier adsorption method. Powder blends containing magnesium trisilicate hydrate (MTSH) or magnesium lluminum silicate (MAS) at various oil loading factors were mixed with MCC with and without various binders and compressed into tablets using a fixed loading force of approximately of 5 KN. Hardness profiles of these oil loaded tablets were then analyzed.Results: Powder compacts which contained MTSH with and without SMEDDS oil had shown relatively better compaction properties than MAS. Adding SMEDDS oil solution to either MTSH or MAS at ratios of 1:9 has relatively reduced tablets hardness by almost 2 or 4 folds, respectively.Conclusion: Progressive inclusion of increasing amounts of SMEDDS oil solution adsorbed unto the solid carrier has incurred a further reduction in the hardness of SMEDDS tablets. It appears that manufacturing of tablet SMEDDS can only be attainable for highly potent drugs as minimal amounts of oil solution added to the powder blends can adversely affect the mechanical strength of compressed tablet.
Authors and Affiliations
Naser M. y. Hasan, Dhaifallah M. Almalki, Mohammed J. k. Althuwaybi, Hassan M. Alshehri
Keywords
Related Articles
- EP ID EP576042
- DOI 10.22159/ijpps.2016v8i9.13409
- Views 77
- Downloads 0
COMPARATIVE COMPOSITIONS AND ANTIBACTERIAL ACTIVITY OF THE ESSENTIAL OILS OF ANTHEMIS NOBILIS L. AND ANTHEMIS MIXTA L. (ASTERACEAE)
Objective: To evaluate the chemical composition of essential oils from aerial parts of Anthemis nobilis (An) and Anthemis mixta L (Am). and investigate their antibacterial property.Methods: The essential oils were isolat...
PURIFICATION AND CHARACTERIZATION OF L-ASPARAGINASE BY PSEUDONOCARDIA ENDOPHYTICA VUK-10 ISOLATED FROM NIZAMPATNAM MANGROVE ECOSYSTEM
Objective: L-asparaginase has been a promising therapeutic agent in the treatment of acute lymphoblastic leukaemia. In the present study a rare actino bacterial strain Pseudonocardia endophytica VUK-10 isolated from Niza...
EICHHORNIA MEDIATED COPPER OXIDE NANOPARTICLES: IN VITRO ANALYSIS OF ANTIMICROBIAL ACTIVITY
Objective: The present investigation determines the biological synthesis and characterization of Copper oxide nanoparticles from aqueous extract of Eichhornia crassipes and assessing its effects on antimicrobial activity...
MOLECULAR DOCKING STUDY OF NEUROPROTECTIVE PLANT-DERIVED BIOMOLECULES IN PARKINSON’S DISEASE
Objective: The objective of this study was to explore the therapeutic role of biomolecules in targeting the altered expression of Parkin in PD pathogenesis.Methods: We employed various in silico tools such as drug-likene...
EXISTING EVIDENCE FOR SAFE USE OF HERBAL MEDICINES IN CHRONIC KINEY DISEASE
There has been a widespread use of herbal medicines in the last two decades, despite a lack of scientific evidence for their efficacy and safety. Health care professionals have expressed growing concerns about safety iss...