Anti-HMGCR Antibody Associated Necrotizing Autoimmune Myopathy-A Case-Based Clinical Review
Journal Title: Journal of Clinical and Medical Research - Year 2019, Vol 1, Issue 1
Abstract
A 54 years gentleman presented with proximal and distal myopathies with a history of statin exposure with persistent symptoms posts statin cessation. CPK ranged from 18000 to 25000 IU/L. Lower limb MRI showed extensive bilateral muscle oedema consistent with myositis. EMG was consistent with an inflammatory myopathic disease. Muscle histopathology revealed evidence of fibers' degeneration and necrosis in the absence of inflammation. Improvement in clinical symptomatology and muscle enzymes showed with pulse steroids and other immunomodulators including Methotrexate, IVIG and Rituximab.
Authors and Affiliations
Aadil Al Ghafri*, Omer Hussein, Trevor Duffy, Eithne Murphy, Maurice Barry
Keywords
Related Articles
- EP ID EP708365
- DOI https://doi.org/10.37191/Mapsci-2582-4333-1(1)-003
- Views 98
- Downloads 0
Home Care for the Elderly, Disabled with a Loss of Autonomy: Care and the Benefit of Care, Follow-Up by Rural Home Care Facilities in Cameroon
The underdeveloped countries in this case Cameroon is conducive to a specific construction of aging, losses suffering from severe chronic diseases debilitating and disabling, people in loss of autonomy. The lack of the t...
Isolation and Identification of Antibiotics Susceptible Staph Aureus from Unprocessed Milk
Milk is luminous white liquid substance produced by mammary gland. The quality of milk is said to be affected because it is perfect culture medium for the growth of micro-organisms. Staphylococcus aureus is a common micr...
Assessment of Health Related Quality of Life, Health Status and Medication Adherence among Patients with Rheumatoid Arthritis in Pakistan
Objectives: The aim of the present study is to assess the medication adherence, health status and health-related quality of life among rheumatoid arthritis patients in Rawalpindi and Islamabad Patients and Methods: A...
EDBCO-19: Emergency Data Base of COVID-19
A coronavirus disease epidemic in 2019 (COVID-19) has occurred in Wuhan China since December 2019 and has quickly spread, now being reported in several countries, approximately 190 out of 252 nations. Screening in high-r...
Presence of Proteins in 17% EDTA after Contact with the Bovine Dentine
EDTA 17% is a solution frequently used in endodontics for the extraction of the mineralized remains of dentine from the root canals. Its chelating action could affect the dentine making it susceptible to insults. The obj...