Anti –Mullerian Hormone is a new Marker for Ovarian function in females with polycystic ovary syndrome
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2019, Vol 14, Issue 1
Abstract
Anti-Mullerian Hormone (AMH) is a member of the transforming growth and differentiation factors in the ovary, AMH has an inhibitory effect on primordial follicle recruitment as well as on the responsiveness of growth follicles to follicle stimulating hormone (FSH) ‘The ovary-specific expression pattern in granulosa cells of growing non selected follicles makes AMH an ideal marker for the size of the ovarian follicle pool. The aims of the present study were as follows: 1) to confirm the increase of serum AMH in patients with PCOS ; 2) to search for any relationship of serum AMH to the other hormonal features of PCOS; 3) whether metformin administration affects serum AMH levels.. Design: case series. Setting: Private clinic of Dr.Luma Al Sarraj and Al Duaa clinical laboratory of Dr.Islam Al Jalili. Participants and Methods: this study was conducted on 75 female subjects aged less than 45 years for the period from March2012-July 2012,infertile women were diagnosed as poly cystic ovary syndrome(PCOS) according Rotterdam Consensus (2004),thirty women were normal (n=30) used as control. Serum AMH hormone was measured using Enzyme Linked Immune Sorbant Assay(ELISA),LH, FSH, Testosterone ,Prolactin were measured by using Enzyme Linked Fluorescent assay(ELFA). Results: There was a significant increase & difference in serum AMH, LH, prolactin while a significant decrease in serum FSH in women with PCOS as compared to control women. Concerning testosterone hormone, there was an increase in its level in women with PCOS but not reached significance when compared to its level in control women. Women with PCOS showed a significant decrease in their serum AMH levels after their treatment with Metformin. The percent improvement rate after treatment with Metformin was 48.12%. There was a significant positive correlation between serum AMH and LH levels in patients with PCOS while no significant correlation was seen between serum AMH and FSH, prolactin and testosterone. Conclusion: Serum levels of AMH were increased in women with PCOS and AMH measurement can be used as a marker with high specificity and sensitivity for PCOS.
Authors and Affiliations
Dr. Luma Alsarraj, Dr. Sajeda Al-Chalabi, Dr. Islam Al Jalili
Keywords
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- EP ID EP441077
- DOI 10.9790/3008-1401016265.
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