Anti-seizure activity of Extract of Jatropha gossypiifolia Linn (Euphorbiaceae)
Journal Title: Tropical Journal of Natural Product Research - Year 2018, Vol 2, Issue 2
Abstract
Received 13 January 2018 Revised 27 January 2018 Accepted 02 February 2018 Published online 07 February 2018 The leaves of Jatropha gossypiifolia has been widely used for the treatment of epilepsy and childhood convulsions in ethnomedicinal practice of Northern Nigeria. In this study, we investigated the anti-seizure claim of this plant part using established scientific protocols. Phytochemical screening and acute toxicity evaluation of the methanol leaf extract were performed while maximal electroshock-induced seizures in cockerels (MEST), pentylenetetrazole (PTZ), strychnine (STN) and 4-aminopyridine (4-AP) induced seizure models were employed in mice. The methanol leaf extract contains cardiac glycosides, steroids, triterpenes, tannins and flavonoids, while the median lethal dose of the extract was estimated to be 1131 mg/kg. In the anti-seizure studies, the extract at all the tested doses (75, 150 and 300 mg/kg) did not delay the recovery time of convulsed cockerels in MEST model nor delay the mean onset of seizures in PTZ and 4-AP models in mice in comparison with controls. Conversely, the extract at 150 mg/kg dose significantly (p ≤ 0.05) delayed the mean onset of seizures in mice in STN model compared to control treatments. In conclusion, this study provided the possible pharmacological basis for the use of Jatropha gossypiifolia leaf in treating seizure conditions.
Authors and Affiliations
Abdullahi H. Yaro, Musa Aliyu Aliyu, Kamaludeen Garba, Sani Hassan
Keywords
Related Articles
- EP ID EP489351
- DOI 10.26538/tjnpr/v2i2.8
- Views 82
- Downloads 0
Aloe vera Prevents Radiation-Induced Dermatitis among the Black Population
Received 15 August 2018 Revised 15 September 2018 Accepted 20 September 2018 Published online 21 September 2018 Radiation-induced dermatitis is a major complication often encountered following radiotherapy, despite new...
Phytochemical Analysis and Hypoglycaemic Activity of the Methanol Stem Bark Extract of Tabernaemontana pachysiphon Stapf (Apocynaceae)
Tabernaemontana pachysiphon Staph. (Apocynaceae) stem bark is used ethnomedicinally for the treatment of diabetes. This study determined the phytochemical constituents and evaluate the methanol stem bark extract for acut...
Impact of Yoyo bitters® on the Pharmacokinetic Profile of Ciprofloxacin in Healthy Nigerian Volunteers
Received 17 September 2018 Revised 09 October 2018 Accepted 12 October 2018 Published online 23 October 2018 Ciprofloxacin and Yoyo bitters® (a liquid herbal oral preparation) are readily and widely available as prescri...
Antinociceptive and Antioxidant Activities of Methanol Extract and Fractions of the Root Bark of Callichilia stenopetala Stapf. (Family Apocynaceae) In Mice
The root of Callichilia stenopetala is used as chewing stick in the treatment of toothache and for oral hygiene in South-East Nigeria. The study assessed the antinociceptive and antioxidant activities of methanol root ba...
Natural Product Synthesis and Drug Discovery: Shortcomings and Successes
Natural products have evolved over the years and several of them have been found to interact with biological macromolecules in intact organisms. Their structural complexity often makes it difficult to produce natural dru...