Natural Product Synthesis and Drug Discovery: Shortcomings and Successes
Journal Title: Tropical Journal of Natural Product Research - Year 2017, Vol 1, Issue 1
Abstract
Natural products have evolved over the years and several of them have been found to interact with biological macromolecules in intact organisms. Their structural complexity often makes it difficult to produce natural drug molecules via chemical synthesis. This limitation can hinder their further development as drugs. Modification of a natural product’s structure by chemical synthesis to address issues of unwanted side effects can also be very difficult. As an alternative to chemical synthesis, the natural products are isolated in commercial quantities from their sources. This however, poses other challenges such as the need to obtain enough raw material in an environmentally sustainable fashion to ensure an adequate supply of the drug. There is also variability in how some substances produce often trace amounts of potential drugs. In the pharmaceutical industry, such drawbacks have led to the deprioritization
Authors and Affiliations
Lee Pedzisa
Formulation and Evaluation of Therapeutic Potential of Nanoemulsion of a Blend of Antimicrobial Oils
Received 30 December 2017 Revised 02 February 2018 Accepted 05 February 2018 Published online 07 February 2018 This work is aimed at producing an effective self-emulsifying nanoformulation of a combination of 9 antimic...
Coconut (Cocos nucifera) and Moringa (Moringa oleifera) Oils Protect Against Cadmium-induced Toxicity in Albino Rats
Received 20 February 2018 Revised 26 March 2018 Accepted 02 April 2018 Published online 07 April 2018 Exposure to heavy metals is currently an increasing source of concern worldwide. The present study evaluated the effe...
Brine Shrimp Cytotoxicity and Anti-Mitotic Activity of Aqueous Root-Bark extract of Securidaca longepedunculata (Polygalaceae
Received 12 July 2017 Revised 13 February 2018 Accepted 21 February 2018 Published online 07 March 2017 Securidaca longepedunculata is a savannah shrub found growing in South-West Nigeria and some other areas in Africa....
Bioassay-coupled Chromatographic Analysis of Medicinal Natural Products: A Review
Medicinal plants have found immense use in drug discovery over the years as several chemically available drugs today are either directly from plant secondary metabolites or have their templates from such. Recent advances...
https://www.tjnpr.org/viewarticle.aspx?articleid=50
There is a growing concern of the potential risk of producing genetically defective sperm and transmitting germ-line mutations to progeny by fathers who prefer their children at old age. Men with male factor infertility...