ANTIAMNESIC POTENTIAL OF SOLASODINE AGAINST β-AMYLOID PROTEIN INDUCED AMNESIA IN MICE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 5
Abstract
Alzheimer’s disease (AD), the most common form of dementia in the elderly population, is characterized by an insidious onset with memory impairment and an inexorable progression of cognitive decline. Nootropic agents are a heterogeneous groups of drugs developed for use in dementia and other cerebral disorders. Nootropics agents are being primarily used to improve memory, mood and behavior. However, the resulting adverse effects associated with these agents have limited their use. Therefore, it is worthwhile to explore the utility of traditional medicines for the treatment of various cognitive disorders. The present study was undertaken to assess the potential of solasodine on β-amyloid induced amnesia in mice. Elevated plus maze (EPM) and Morris water maze (MWM) was employed to evaluate learning and memory parameters. Piracetam was used as the standard drug. Solasodine (1, 2 and 4 mg/kg, p.o.) was screened for claimed potential in mice. Solasodine improved both short term memory and long term memory when assessed on Elevated pluz maze and Morris Water maze respectively. Hence, solasodine might prove to be a useful memory restorative agent in the treatment of dementia seen in the Alzheimer’s disease.
Authors and Affiliations
Alpesh Desai , Virendra Kagathara , Chetan Desai , Suresh Patel , Vijay Patel
Keywords
Related Articles
- EP ID EP108527
- DOI -
- Views 133
- Downloads 0
ETHNO BOTANICAL SURVEY OF PLANTS USED BY FOLKLORE PRACTITIONERS OF HAVERI DISTRICT, KARNATAKA, INDIA IN TREATING SEPTIC CONDITIONS WITH SPECIAL REFERENCE TO ACACIA FARNESIANA LINN AND PERGULARIA DAEMIA LINN AND THEIR ANTI BACTERIAL ACTIVITY
Ayurveda is time tested , treasured and archaistic science. 70% of India’s medicinal plants are found in the tropical zone. Mixed vegetation of both wet and dry landscape of Haveri district sources a variety of medicinal...
IMPROVEMENT OF SOLUBILITY AND DISSOLUTION RATE OF MEFENAMIC ACID BY SOLID DISPERSIONS IN PEG4000
The aim of this study was to prepare and characterize solid dispersions of water insoluble non-steroidal anti-inflammatory drug, mefenamic acid (MA), with polyethylene glycol 4000 (PEG4000) for enhancing the dissolution...
ANTIHYPERLIPIDEMIC ACTIVITY OF DIVYA METHIPACHAK AGAINST TRITON X-100 INDUCED HYPERLIPIDEMIA IN RATS
The present study was designed to evaluate the anti-hyperlipidemic activity of Divya Methipachak a polyherbal formulation against triton induced hyperlipidemia in rats. Hyperlipidemia was induced by Triton X-100 (100 mg/...
EVALUATION OF ANTIOXIDANT POTENTIAL OF RHIZOME EXTRACTS OF TWO SPECIES OF ALPINIA ROXB. (ZINGIBERACEAE)
Objective of the present study was to investigate the in vitro antioxidant activities of methanolic extracts of the rhizomes of A. smithiae and A. vittata. Both the extracts exhibited their scavenging effects in a concen...
AN OVERVIEW ON VARIOUS APPROACHES TO ORAL CONTROLLED DRUG DELIVERY SYSTEM VIA GASTRORETENTIVE DRUG DELIVERY SYSTEM
In recent years scientific and technological advancements have been made in the research and development of oral drug delivery system. Oral sustained drug delivery system is complicated by limited gastric residence times...