ANTIANXIETY AND ANTIDEPRESSANT ACTIVITY OF VALERIANA PYROLAEFOLIA
Journal Title: International Journal of Pharmaceutical Sciences and Research (IJPSR) - Year 2019, Vol 10, Issue 10
Abstract
Aim of the present study was to evaluate the antianxiety and antidepressant activity of Valeriana pyrolaefolia, a member of family Valerianaceae. The antianxiety and antidepressant activities of dichloromethane extract were evaluated using the elevated plus-maze model and porsolt’s despair swim test. The studies were conducted on lacca mice, and the test materials were administered per oral route. The dichloromethane extract of V. pyrolaefolia roots exhibited significant dose-dependent antianxiety activity at 400 mg/kg. The results were comparable to the standard diazepam (2 mg/kg). The extract also exhibited significant antidepressant activity at 400 mg/kg dose. The results were comparable to the standard imipramine (10 mg/kg). The TLC fingerprint profile of the bioactive extract was developed using precoated TLC plates of 0.2 mm thickness. Valtrate was used as a bioactive marker for developing TLC fingerprint profile. The solvent system comprising dichloromethane: ethyl methyl ketone (8: 2) was used for developing the TLC profile. The TL chromatogram showed valtrate as a major component of the extract.
Authors and Affiliations
A. Kumar et al.
Keywords
Related Articles
- EP ID EP656752
- DOI 10.13040/IJPSR.0975-8232.10(10).4526-30
- Views 108
- Downloads 0
DRUG UTILIZATION PATTERN IN GERIATRIC PATIENTS OF GENERAL MEDICINE IN A SECONDARY CARE HOSPITAL
The purpose of the research was to assess the prescribing pattern in geriatrics and to analyze the prescription using World Health Organization (WHO) core prescribing indicators and American Geriatric Society (AGS) Beers...
SYNTHESIS, CHARACTERIZATION AND BINDING PROPERTIES TOWARDS CT-DNA OF MIXED-LIGAND Cu(II) COMPLEX WITH 2-AMINOBENZONITRLE AND OCTANOATE ION
A novel coordination complex of 2-aminobenzonitrile (ABN) and octanoate ion (OC) with Cu(II) metal ion has been prepared by using microwave irradiation. The molecular formula and the geometry of the complex have been ded...
STABILITY INDICATING RP-HPLC METHOD FOR THE SIMULTANEOUS ESTIMATION OF PANTOPRAZOLE AND LEVOSULPIRIDE IN PHARMACEUTICAL DOSAGE FORM
Simple, sensitive, and rapid stability indicating RP-HPLC method for simultaneous estimation of Pantoprazole and Levosulpiride in pharmaceutical dosage form was developed and validated. The analysis was carried out on Hi...
THERAPEUTIC EFFECT OF TAMARINDUS INDICA EXTRACTS ON THE PATHOGENESIS OF ENTAMOEBA HISTOLYTICA IN-VIVO
Entamoeba histolytic is a protozoan parasite which causes amoebiasis, about 50 million people are affected yearly, and it caused more than 100,000 deaths per year. The study investigates the therapeutic effect of ethanol...
MOLECULAR DOCKING STUDIES OF ORGANOSULFUR COMPOUNDS AND FLAVONOIDS OF ALLIUM SATIVUM AGAINST EGFR TO TREAT NON-SMALL CELL LUNG CANCER
Lung cancer is one of predominant cancer which leads to death in the developed and developing countries. 80% of lung cancer cases in India are reported as Non-Small Cell Lung Cancer (NSCLC). EGFR (Epidermal growth factor...