Antibacterial Activity of Commiphoramolmol Extracts on Some Bacterial Species in Iraq
Journal Title: Scholars Academic Journal of Pharmacy - Year 2016, Vol 5, Issue 12
Abstract
Abstract:This study aimed to evaluate the inhibitory effect ofCommiphoramolmol(Myrrh) extracts on the growth of Staphylococcus aureus, Escherichia coli, Klebsiellapneumoniae, Pseudomonas aeruginosaand Acinetobacterbaumanniifrom Iraqi hospital isolates. The chloroform, methanol and water extracts of C. molmol were tested against the five clinical microbial strains.Gel diffusion method, minimum inhibitory concentration (MIC) values were used in this study. Also Phytochemical analysis of most biological active extract was determined by general phytochemical screening and GCMS, The findings indicated that C. molmolmethanol and chloroformextracts had growth inhibitory effect against tested bacteria. Methanolic extract of C. molmolexhibited the highest inhibitory effect on all tested microorganisms, MIC of methanolic extract was 3.12mg/mL for each of E.coli, K.pneumoniae and P.aeruginosa, 12.5mg/mL for A.baumannii and 6.25mg/mL for S.aureus. Phytochemical screening showed the presence ofterpenoids, tannins, alkaloids, saponins and flavonoids. GC MS investigation of C. molmolmethanol extract showed the different peaks of the different constitutes with highest intensity that recorded β-elemene (classified as sesquiterpenes) with retention time 10.82 and other sesquiterpenes constitutes showing that the resin is rich in sesqiuterpenes that possess the antibacterial activity. Keywords:Commiphoramolmol, Antibacterial Activity,Staphylococcus aureus, Escherichia coli, Klebsiellapneumoniae.
Authors and Affiliations
Dalya B. Hana, Haitham M. Kadhim, Ghaith A Jasim, Qabas N Latif
Keywords
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