ANTIDEPRESSANT ACTIVITY OF HYDROALCOHOLIC EXTRACT OF ZINGIBER OFFICINALE
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 2
Abstract
The present study was design to evaluate the effect of Zingiber officinale hydro-alcoholic extract as well as its interaction with conventional anxiolytic and antidepressant drugs using tail suspension test and forced swim test (FST) and to evaluate the possible mechanisms involved in its actions. The rhizomes of ginger were collected and authenticated. Extraction of dried rhizomes was carried out using soxhlet apparatus to obtain its Hydro alcoholic extract. The extract of Zingiber officinale showed the significant antidepressant activity comparable to the standard drug. The oral administration of Zingiber officinale extract at 150 mg/ kg and 300 mg/kg respectively as compared to the control treated group showed an antidepressant activity comparable to that of standard drug. The antidepressant effects of Zingiber officinale extract seem to be mainly associated with the activation of dopamineergic system and possess potential anxiolytic and antidepressant activities.
Authors and Affiliations
Rudra Singh , Ritesh Jain , Rahul Mishra , Prashant Tiwari
Keywords
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