ANTIDIABETIC AND ANTIHYPERLIPIDEMIC ACTIVITY OF BARK OF CASUARINA EQUISETIFOLIA ON STREPTOZOTOCIN INDUCED DIABETIC RATS
Journal Title: Int J of Pharm Rev& Res - Year 2011, Vol 1, Issue 1
Abstract
The present study was aimed to evaluate the anti diabetic - activity potential of Casuarina equisetifolia leaves against streptozotocin (STZ) induced experimental rats. Ethanolic extract of bark of Casuarina equisetifolia (EECE) was administered to streptozotocin induced rats. Glibenclamide was used as a standard drug. Blood glucose levels were determined after oral administration of a dose of Casuarina equisetifolia (400 mg/kg b. wt) in diabetic groups. Blood glucose levels were determined on 0, 7th, 14th and 21st day after oral administration of ethanolic extracts of Casuarina equisetifolia (400 mg/kg). An ethanolic extract of Casuarina equisetifolia was found to reduce blood sugar in streptozotocin induced diabetic rats. Reduction in blood sugar could be seen from 7th day after continuous administration of the extract. The effect of extracts of Casuarina equisetifolia on serum lipid profile like Total cholesterol, triglycerides, low density, very low density and high density lipoprotein were also measured in the diabetic and non diabetic rats. There was significant reduction in Total cholesterol, LDL cholesterol, VLDL cholesterol and improvement in HDL cholesterol in diabetic rats. These results indicated that Casuarina equisetifolia possesses a hypoglycemic and antihyperlipidemic effect.
Authors and Affiliations
*N. Sriram
Keywords
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