Antidiabetic and Cytoprotective Effect of Ethanolic Extract of SalaciaNitida Root on Alloxan-Induced Diabetic Rats
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 1
Abstract
Objective:Many of the available therapies for diabetes have a number of serious adverse effects; therefore the search for more effective and safer hypoglycaemic agents becomes a paramount. This research was set to investigate the antidiabetic potential and cytoprotective effect of ethanolic root extract of Salacianitida on alloxan induced hyperglyceamic rats. Method:Acute toxicity and phytochemical constituents were evaluated using standardized methods. The study lasted for a period of thirty days comprising of two phases: induction phase and treatment phase. Thirty animals were grouped into five groups of six rats each. Group 1 and 2 serve as normal and toxic control respectively while groups 3, 4, and 5 were treated with 750, 1500mg of S.nitidaand 5mg glibenclamide respectively. The BGL, food and fluid intake was monitored daily while the body weight was measured on weekly. The last day of the study after an overnight fast, the animals were loaded with glucose and the OGTT measured prior to and at 30minutes interval for two hours after which the animals were sacrificed under ether anaesthesia and the organs isolated for histological examination. Results/Conclusion:The results of the present study indicate that S.nitida possessantidiabetic potentials and cytoprotective effect noted in its significant percentage reduction in the glucose level, slight increase in body weight and restoration of the toxic organs to normal.
Authors and Affiliations
Dooka B. D 1, Ezejiofor A. N1
Keywords
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- EP ID EP388238
- DOI 10.9790/3008-1201038793
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