Testosterone Concentration and Testicular Histomorphology of Rats Exposed to Hippocratea Africana Root Bark Extract
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 2
Abstract
Malaria is a scourge of the tropical region of the world, affecting mostly the poor who cannot afford the World Health Organisation (WHO) recommended artemisinin combination therapy. This results in the continuous reliance on herbal remedies for the treatment of the disease. Hippocratea africana is one of the herbs used traditionally for the treatment of malaria in South Eastern region of Nigeria. Testosterone concentration and testicular histomorphology were assayed to assess the effect of the herb on male reproductive function. Experimental groups were formed as follows; control group 1 administered 1ml of distilled water and test groups II, II and IV administered 100, 200, and 300 mg/kg body weight of the root bark extract. One-way analysis of variance (ANOVA) and Student’s Test (t- test) were used for statistical analyses. The result showed significant (p < 0.05) increase in the concentration of testosterone in all the test groups compared with the control in a dose dependent manner. There was no evidence of pathology on the photomicrographs of the testes of all the test groups compared with the control. The results show that the herb did not cause lesions and degenerative changes in the testes and improved testicular steriodogenesis and so maybe safe for its use as an antiplasmodial agent.
Authors and Affiliations
* Jessie Idongesit Ndem,, Victor Eno Johnson
Keywords
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- EP ID EP388372
- DOI 10.9790/3008-1202011317
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