ANTIMICROBIAL AND ANTIOXIDANT ACTIVITIES OF SOME NEWLY SYNTHESIZED BENZENE-1, 3-DIOL CONGENERS AND THEIR CHARACTERIZATION
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 7
Abstract
Objective: Synthesis of novel Benzene-1, 3-diol analogues by incorporation of various aryl and hetero arylazo moieties. The newly synthesized Benzene-1, 3-diol congeners were evaluated to study their in vitro antimicrobial and antioxidant activities.Methods: This part of research work was included with the synthesis of a series of Benzene-1, 3-diol analogues by coupling of Benzene-1, 3-diol with different diazotized aryl and heteroaryl amines and their structures and physical characteristics were confirmed by different modern analytical techniques viz. FT/IR, 1H NMR, UV spectroscopy, LC-MS, DSC and elemental analysis. The in vitro antimicrobial activity of the synthesized compounds were conducted by cup and plate method against different gram positive and gram negative bacterial pathogens and fungal strains. The radical scavenging activity of the Benzene-1, 3-diol analogues were measured by DPPH method. The results of antimicrobial and antioxidant activity were statistically interpreted.Results: The newly synthesized compounds of Benzene-1, 3-diol substituted with 4-carboxy phenyl, antipyrinyl and isoxazolyl nucleus showed significant antibacterial activity. Whereas, the antipyrinyl and isoxazolyl substitued benzene-1, 3-diol analogues showed significant antifungal activities when compared with standard drugs. The Benzene-1, 3-diol analogues also exhibited effective antioxidant activity.Conclusion: This research work concluded that the newly synthesized benzene-1, 3-diol analogues posses significant antimicrobial and potential antioxidant activity.
Authors and Affiliations
Sudhir Kumar Paidesetty, Susanta Kumar Rout, Jyotirmaya Sahoo
Keywords
Related Articles
- EP ID EP578597
- DOI -
- Views 56
- Downloads 0
PHARMACOLOGICAL EVALUATION OF HYDROALCOHOL AND CHLOROFORM EXTRACTS OF NYCTANTHES ARBOUR-TRISTIS L. FOR ANTIOXIDANT, ANTI-INFLAMMATORY AND ANALGESIC ACTIVITY
Objective: The study was designed to evaluate the anti-oxidant, anti-inflammatory and analgesic activity of hydroalcohol (HA) and chloroform (CH) extracts of the whole plant of Nyctanthes Arbour-tristis L in laboratory a...
ANTIOXIDANT AND ANTI-INFLAMMATORY ACTIVITY OF THE INDONESIAN FERNS, NEPHROLEPIS FALCATA AND PYRROSIA LANCEOLATA
Objective: The aim of this research is to evaluate antioxidant and anti-inflammatory activity of extracts of the Indonesian ferns Nephrolepis falcata and Pyrrosia lanceolata.Methods: Antioxidant activity was measured by...
A STUDY COMPARING THE ANORECTIC ACTIVITY OF HOT AND COLD AQUEOUS EXTRACTS OF DOLICHOS BIFLORUS LINN. SEEDS IN FREELY FEEDING RATS
Objective: The aim of the study was to evaluate the anorectic activity of hot (pre-cooked under pressure) and cold (soaked overnight) aqueous extracts of the seeds of D. biflorus in freely feeding Wistar albino rat model...
SYNTHESIS OF NOVEL γ-CARBOLINE DERIVATIVES AND THEIR IN SILICO STUDIES ON 5HT1, H1 AND CCR2 ANTAGONIST RECEPTORS
Objective: Synthesis of novel γ-carboline precursor 4 by using mild, inexpensive and eco friendly T3Methods: The reaction was carried out by taking mixture of 1 equiv. of phenyl hydrazine hydrochloride, 1 equiv. of N-Bo...
RP-HPLC METHOD DEVELOPMENT AND VALIDATION FOR SIMULTANEOUS QUANTITATIVE ESTIMATION OF DILOXANIDE FUROATE AND ORNIDAZOLE IN TABLETS
Objective: To develop an accurate, precise and linear Reverse Phase High Performance Liquid Chromatographic (RP-HPLC) method for simultaneous quantitative estimation of Diloxanide furoate and Ornidazole in tablets and va...