Antinociceptive and Anti-Inflammatory Properties of the Methanol Leaf Extract of Argyreia argentea
Journal Title: Journal of Pharmaceutical Sciences and Research - Year 2010, Vol 2, Issue 8
Abstract
The present study was carried out to investigate the antinociceptive and anti-inflammatory properties of methanol leaf extract of Argyreia argentea. Antinociceptive properties of the extract were evaluated on the pain induced by acetic acid and formalin in Swiss albino mice. The extract at a dose of 1, 1.5 and 2 gkg-1 produced an inhibition of 15.81%, 52.91% and 58.71% on acetic acid induced pain and an inhibition of 29.56%, 39.51% and 45.96% on formalin induced pain. Oral administration of the extract significantly (P<0.001 and P<0.01) reduced writhing response induced by acetic acid and licking response induced by formalin. The anti-inflammatory activity of the same extract was estimated by measuring the mean increase in hind paw volume of carrageenan-induced Wistar albino rat with the help of plethysmometer. Oral administration of extract at a dose of 0.5, 1.0 and 1.5 gkg -1 showed the highest inhibition 25.92%, 37.03%, and 34.57%, respectively at the 4th hour of administration. Argyreia argentea extract showed significant (P<0.001 and P<0.01) effect in the reduction of the paw edema induced by carrageenan. The degree of anti-inflammatory and antinociceptive activity of extract was compared to the effect of standard drug diclofenac sodium. Morphine is used as a standard drug in formalin induced licking response model. In acute toxicity study, no mortality was observed at 4 gkg-1 dose level. The present study demonstrates the potential anti-inflammatory and analgesic effect of the methanol leaf extract of Argyreia argentea which supports the claims by the traditional medicine practitioner
Authors and Affiliations
Uddin MN , Begum J , Rahman MA , Ahmed NU , Akter R , Abdullah AM
Keywords
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