Antinociceptive and cytotoxic potential of ethanolic extract of Delonix regia (Leaves)
Journal Title: Indian Journal of Pharmaceutical and Biological Research - Year 2014, Vol 2, Issue 1
Abstract
This study investigated the antinociceptive and cytotoxic effects of alcoholic extract of Delonix regia Leaves in rodents. Antinociceptive activities were done using paw licking and writhing tests. The extract was used at dose of 200 and 400 mg/kg per orally as compared to Standard drug Diclofenac-Na 100 mg/kg bw in Swiss albino mice of body weight 25-30 g. The cytotoxic activity was determined by the Brine Shrimp lethality bioassay. The alcoholic extract showed very highly significant effect in formalin test (p<0.01). Also had the highest analgesia (p<0.001) in the acetic acid-induced writhing model as well. The extract possessed a good in vitro cytotoxic activity (LC50=4.06 μg/ml). The results suggested that Delonix regia Leaves extract has a suitable antinociceptive effect as well as cytotoxic potential.
Authors and Affiliations
Rozina Parul| Department of Pharmacy, Gono Bishwabidyalay, Savar, Dhaka-1344, Md. Jahir Alam| Department of Pharmacy Practice, North South University, Bashundhara, Dhaka-1229, Md. Sohel Rana| Department of Pharmacy , Jahangirnagar University, Savar, Dhaka- 1342
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