ANTIOXIDANT AND ANTIMICROBIAL ACTIVITIES OF TABERNAEMONTANA HEYNEANA WALL. AN ENDEMIC PLANT OF WESTERN GHATS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 7
Abstract
Objective: The aim of this study was to investigate the antioxidant and antimicrobial properties of different crude extracts of leaves of T. heyneanaMethods: Crude extracts of methanol, chloroform, dichloromethane and dichloroethane of leaf were evaluated for antimicrobial activity by disc diffusion method and antioxidant activity by DPPH (diphenyl-2-picrylhydrazyl) and reducing power assay. Quantitative analysis of total phenolics was done by Folin-Ciocalteau method and total flavonoids by aluminium chloride method.Results: Methanolic extract of T. heyneana exhibited the presence of all the phytochemicals tested except triterpenoids and saponins. The highest phenolic content of 14.0±0.45 mg GAE/g and flavonoid content of 81.62±0.47 mg QE/g were found in methanol extract. The highest DPPH scavenging activity (IC50 20.3±0.56 µg/ml) and reducing power was exhibited by methanolic extract. The methanolic extract showed maximum antibacterial activity of 12.66±0.57 mm zone of inhibition against Staphylococcus aureus and least of 9.23±0.25 mm against Proteus vulgaris.Conclusion: These findings provide scientific evidence to support the traditional use of Tabernaemontana heyneana Wall. and also indicate that the leaves of this species are a promising potential for the development of antioxidant and antimicrobial agents.
Authors and Affiliations
Manasa D. J. , K. R. Chandrashekar
Keywords
Related Articles
- EP ID EP578572
- DOI -
- Views 60
- Downloads 0
SOLUBILITY ENHANCEMENT OF LURASIDONE HYDROCHLORIDE BY PREPARING SMEDDS
Objective: The objective of the study was to enhance solubility of Lurasidone HCl, an atypical antipsychotic drug, by formulating self-micro emulsifying drug delivery system (SMEDDS) and its characterization.Methods: Sol...
APPLICATION OF HPTLC FOR THE QUALITATIVE AND QUANTITATIVE ANALYSIS OF AVOBENZONE, OXYBENZONE, OCTINOXATE IN SUNSCREEN CREAM
Objective: This paper presents the development of an improved method for the Qualitative and Quantitative analysis of Avobenzone(AVO), Oxybenzone(OXY) and Octinoxate(OCTI) using high-performance thin-layer chromatography...
PHYTOCHEMICAL ANALYSIS OF N-HEXANE LEAF EXTRACT OF ALPINIA PURPURATA (VIEILL.) K. SCHUM USING UV-VIS, FTIR AND GC-MS
Objective: The present study was carried out to characterize bioactive constituents present in n-hexane leaf extract of Alpinia purpurata (Vieill.) K. Schum.Methods: Phytochemical screening of the leaf extract of Alpinia...
DESIGN AND DEVELOPMENT OF NOVEL MICROEMULSION BASED TOPICAL FORMULATION OF HESPERIDIN
Objective: Bioflavonoid hesperidin is used primarily to assist treatment of capillary disorders like hemorrhoids and varicose veins, by reducing capillary permeability. There are certain limitations to the use of these b...
SYNTHESIS OF WOUND-HEALING KERATIN HYDROGELS USING CHICKEN FEATHERS PROTEINS AND ITS PROPERTIES
Objective: A novel cross-linked keratin hydrogel was prepared by integrating keratin from chicken feather into an aloe-vera, Chitosan and honey based dressing formulation separately.Methods: Keratin fibres extracted from...