RELATIONSHIP BETWEEN UNDERCARBOXYLATED OSTEOCALCIN AND OSTEOPROTEGERIN IN KNEE OSTEOARTHRITIS
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2014, Vol 6, Issue 11
Abstract
Objective: The purpose of the present study was to evaluate the possible association between the serum levels of undercarboxylated osteocalcin (ucOC) and osteoprotegerin (OPG) in patients with knee osteoarthritis (OA).Methods: Twenty patients (10 men and 10 women) diagnosed to have knee OA, and twenty healthy subjects of matching age, sex, and BMI as a control group, were enrolled in this study. Serum levels of ucOC and OPG, were assayed using the corresponding human ELISA kits.Results: Patients with knee OA, showed a statistically significant elevation in serum levels of ucOC (P<0.001), and a statistically significant reduction in that of OPG (P<0.0001), as compared to the control group. Also, there is significant negative correlation (r=-0.554, p= 0.0113) between the serum levels of ucOC and OPG in knee OA patients.Conclusion: there is possible association between the serum levels of ucOC and OPG in patients with knee OA.Â
Authors and Affiliations
Shatha H Ali, Ali A. Kassim
Keywords
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